T. Willson

Pharmacology · 2000–2021

A researcher in the Science corpus: 22 papers; trusts 1 researcher and is trusted by 8 researchers here, as inferred from the citation graph.

Subfields

• Pharmacology — 17 citations into it; #721 of 1,112 by trust here, #55 by citations

Whom T. Willson trusts overall

Their strongest outbound trust, strongest first, inferred from their citations.

1. S. Kliewer

Who trusts T. Willson overall

1. D. Moller
2. S. Kersten
3. B. Grygiel-Górniak

Papers from T. Willson's perspective

Ordered by how strongly the researchers T. Willson trusts endorse each paper. Same corpus, a different order for every researcher.

1. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. (Cell)
2. Humanized xenobiotic response in mice expressing nuclear receptor SXR (Nature)
3. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity (Proceedings of the National Academy of Sciences of the United States of America)
4. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids (Proceedings of the National Academy of Sciences of the United States of America)
5. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. (Cell)
6. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux (Nature Medicine)
7. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. (Journal of Biological Chemistry)
8. Therapeutic roles of peroxisome proliferator-activated receptor agonists. (Diabetes)
9. Liver X receptors as integrators of metabolic and inflammatory signaling. (Journal of Clinical Investigation)
10. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ (Nature)

Their papers

• Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. (2000) — 1,180 citations
• Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice (2000) — 807 citations
• The promise and peril of chemical probes (2015) — 739 citations
• Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity* (2000) — 634 citations
• A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ (2005) — 1,315 citations
• Synthetic LXR ligand inhibits the development of atherosclerosis in mice (2002) — 993 citations
• The PPARs: from orphan receptors to drug discovery. (2000) — 1,706 citations
• Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα (2002) — 630 citations
• Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. (2006) — 939 citations
• Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. (2007) — 599 citations
• The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. (2000) — 668 citations
• Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. (2002) — 792 citations
• CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding (2021) — 83 citations
• ApoE promotes the proteolytic degradation of Abeta. (2008) — 921 citations
• 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. (2002) — 736 citations
• Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor* (2002) — 961 citations
• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. (2002) — 959 citations
• The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity (2001) — 755 citations
• The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity (2001) — 1,411 citations
• St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. (2000) — 927 citations