The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.

By S. Kliewer, B. Goodwin, T. Willson. Endocrine reviews, 2002

959 citations recorded by the source corpus.

Subfields: Genetics, Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d64b5c8be6a07161db7a49902be6ba856dba1b4f

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1. J. Hengstler
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6. P. Maurel
7. J. Kenna
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Citations in the corpus

• Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies (2007, background): “Inducers of PXR-mediated CYP3A4 include natural glucocorticoids and synthetic steroids as well as a wide spectrum of xenobiotics (Drocourt et al., 2001; Goodwin et al., 2002; Kliewer et al., 2002; Waxman, 1999).”