A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

By G. Pascual, Amy L. Fong, S. Ogawa, A. Gamliel, Andrew C. Li, V. Perissi, D. Rose, T. Willson, Michael G. Rosenfeld, Christopher K. Glass. Nature, 2005

1,315 citations recorded by the source corpus.

Subfields: Cancer Research, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/145d5e26eb2649bc0464780f7fa987044e11eb8e

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Citations in the corpus

Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “This results in a significant decrease in the expression of pro-inflammatory cytokines (Pascual et al., 2005; Vavassori et al., 2009).”
Overview of Nomenclature of Nuclear Receptors (2006, background): “:3) to corepressor complexes on inflammatory gene promoters (Pascual et al., 2005).”
The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity1 (2009, background): “A putative consensus sequence for SUMO, KEE, was identified on the currently available three-dimensional structures of the LBD of FXR (11).”
Macrophage activation and its role in repair and pathology after spinal cord injury. (2015, background): “PPARγ is also able to bind to transcriptional coactivators, such as steroid receptor coactivator 1 or p300/CBP, inhibiting AP-1 activation and reducing NF-κB-dependent gene expression (Pascual et al., 2005; Brüne et al., 2013).”
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. (2007, methodology): “SUMOylation of PPARg and its interaction with the NCoR complex have been shown to block signal-dependent recruitment of UbcH5 to the inos promoter (Pascual et al., 2005), but whether this is due to inhibition of Tbl1/TblR1 phosphorylation or some distal step remains to be defined.”
Integration of metabolism and inflammation by lipid-activated nuclear receptors (2008, background): “A study by Christopher Glass and colleagues has made considerable advances in determining the molecular events that underlie PPAR-mediated transrepression in macrophage”
The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives (2018, background): “The anti-inflammatory actions of thiazolidinediones through binding and activation to the peroxisome proliferator-activated receptor gamma (PPARgamma), seems to be related to trans-repression of NF-kappaB and reduced expression of NF-kappaB targets.(143)”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “In addition, TZDs have antiinflammatory effects including transrepression of TNF production by macrophages and decreased macrophage infiltration of adipose tissue (Xu et al. 2003; Di Gregorio et al. 2005; Pascual et al. 2005).”