The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

By T. Synold, I. Dussault, B. M. Forman. Nature Medicine, 2001

871 citations recorded by the source corpus.

Subfields: Genetics, Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/c03c7748f980c13e20db40c4a1568fe9a74c9f88

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Mathieu Vinken

In Oncology

1. Christoph Borner
2. C. Klaassen
3. Lauren M. Aleksunes
4. J. Y. Chiang

In Pharmacology

1. B. Goodwin
2. S. Kliewer
3. T. Willson

Citations in the corpus

• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “FXR appears to act as a cell protecting biosensor for intestinal and hepatic cells against bile acid overload by (1) increasing the expression of transport proteins that support the elimination of bile acids from the cell (BSEP, MRP2) and bile acid detoxification (Maglich et al. 2002; Synold et al. ”
• Polymorphisms in Human MDR1 (P‐glycoprotein): Recent Advances and Clinical Relevance (2004, background): “An important regulator of P-gp expression appears to be pregnane X receptor (PXR), a ligand-activated transcription factor well known for its ability to regulate CYP3A4 expression.(86)”
• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. (2002, background): “Functional DR-4 response elements have been identified in the promoter regions of several genes regulated by PXR, including various CYP2B family members (92, 93) and the MDR1 (Fig.”
• Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. (2002, background): “…several additional genes encoding proteins involved in xenobiotic metabolism, including multidrug resistance protein 1 (MDR1) (Geick et al., 2001; Synold et al., 2001), multidrug resistance-associated protein 2 (MRP2) (Dussault et al., 2001; Kast et al., 2002), and organic anion transporter…”
• Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, background): “PXR activation can up-regulate human MDR1 expression in hepatocytes and intestinal cells in vitro (Synold et al., 2001).”