S. Kliewer

Pharmacology · 1993–2011

A researcher in the Science corpus: 21 papers; trusts 2 researchers and is trusted by 3 researchers here, as inferred from the citation graph.

Subfields

• Pharmacology — 19 citations into it; #735 of 1,112 by trust here, #57 by citations

Whom S. Kliewer trusts overall

Their strongest outbound trust, strongest first, inferred from their citations.

1. B. Goodwin

Who trusts S. Kliewer overall

1. J. Y. Chiang
2. B. Goodwin
3. T. Willson

Papers from S. Kliewer's perspective

Ordered by how strongly the researchers S. Kliewer trusts endorse each paper. Same corpus, a different order for every researcher.

1. Humanized xenobiotic response in mice expressing nuclear receptor SXR (Nature)
2. Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor* (Journal of Biological Chemistry)
3. Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands* (Journal of Biological Chemistry)
4. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux (Nature Medicine)
5. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids (Proceedings of the National Academy of Sciences of the United States of America)
6. Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor* (Journal of Biological Chemistry)
7. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity (Proceedings of the National Academy of Sciences of the United States of America)
8. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase (Proceedings of the National Academy of Sciences of the United States of America)
9. Fibroblast growth factors. (Current Biology)
10. The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity (Science)

Their papers

• Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. (2000) — 1,180 citations
• Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. (2007) — 1,532 citations
• Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα (2002) — 630 citations
• FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response (2009) — 730 citations
• Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21* (2007) — 717 citations
• The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. (2000) — 668 citations
• Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. (2003) — 718 citations
• A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport (2001) — 1,100 citations
• FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis (2011) — 608 citations
• Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. (2010) — 694 citations
• Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. (2006) — 1,117 citations
• Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. (2005) — 1,800 citations
• Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. (2002) — 686 citations
• Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor* (2002) — 961 citations
• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. (2002) — 959 citations
• The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity (2001) — 755 citations
• The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity (2001) — 1,411 citations
• St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. (2000) — 927 citations
• Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands* (2000) — 849 citations
• A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. (2000) — 1,900 citations