Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma.

By S. Ghisletti, W. Huang, S. Ogawa, G. Pascual, Mu-En Lin, T. Willson, Michael G. Rosenfeld, Christopher K. Glass. Molecules and Cells, 2007

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Integration of metabolism and inflammation by lipid-activated nuclear receptors (2008, background): “A similar, but not identical, mechanism has recently been elucidated for LXR”
Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells (2010, background): “Subsequent studies of the LXRs, which suppress an overlapping but distinct subset of inflammatory genes in macrophages, indicated that these receptors also suppress inflammatory responses by preventing NCoR turnove”
Apoptotic cells promote their own clearance and immune tolerance through activation of LXR (2009, unknown): “Pharmaco- logically activated LXRs have also been shown to transrepress inflammatory gene expression (Castrillo et al., 2003a; Ghisletti et al., 2007; Joseph et al., 2003).”
LXR signaling couples sterol metabolism to proliferation in the acquired immune response (2008, background): “Recent studies have suggested that LXR-dependent repression of inflammatory target genes occurs via an N-CoR- and sumoylation-dependent process (Ghisletti et al., 2007).”