The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

By Stacey A. Jones, L. Moore, J. L. Shenk, G. Wisely, G. Hamilton, D. D. Mckee, N. Tomkinson, E. LeCluyse, M. Lambert, T. Willson and 3 more. Molecular Endocrinology, 2000

668 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/47babee6bb8a4a813eae4fb8148fe2c62ebd9066

How researchers see this paper

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In Molecular Biology

1. D. Mangelsdorf
2. M. Traber
3. J. Repa
4. J. Atkinson
5. P. Tontonoz
6. Liangyou Rui
7. Christopher K. Glass

In Pharmacology

1. B. Goodwin
2. S. Kliewer
3. T. Willson

Citations in the corpus

• Role of LXRs in control of lipogenesis. (2000, background): “PXR, a nuclear receptor involved in the CYP3A-mediated metabolism of a diverse collection of xenobiotics, is 2832 GENES & DEVELOPMENT known to be activated by a large number of synthetic compounds (Jones et al. 2000).”
• Induction of phase I, II and III drug metabolism/transport by xenobiotics (2005, background): “On the other hand, PCN is a potent rat and mouse CYP3A inducer, but not of human or rabbit CYP3A, and was found also to be a potent rat PXR activator, having very little effect on human and rabbit PXR (Jones et aL, 2000; Staudinger et aL, 2001a, 2001b).”
• A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. (2000, methodology): “The following double-stranded oligonucleotides Transient transfection of CV-1 cells was performed exactly as de- were used as probes and competitors in EMSA: rSHP, 59-gatcCCTG scribed elsewhere (Jones et al., 2000).”
• The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism (2000, neutral): “However, PB is a better agonist ligand for the related receptor SXR/PXR than for CA”
• Vitamin E, antioxidant and nothing more. (2007, background): “Indeed, PXR has been called promiscuous in its ability to bind a variety of ligands [116].”