The promise and peril of chemical probes
By C. Arrowsmith, J. Audia, Christopher M. Austin, J. Baell, J. Bennett, J. Blagg, C. Bountra, P. Brennan, P. Brown, M. Bunnage and 44 more. Nature Chemical Biology, 2015
739 citations recorded by the source corpus.
Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.
Subfields: Computational Theory and Mathematics, Molecular Biology, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/2382bc81fdf11fdde818354cccf2b1929f84842b
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Citations in the corpus
- Rational design of ASCT2 inhibitors using an integrated experimental-computational approach (2021, background): “Notably, a useful chemical probe needs to be validated experimentally using orthogonal assays (39).”
- Open Targets Platform: supporting systematic drug–target identification and prioritisation (2020, neutral): “Other recent additions, such as the chemical probes or the target enabling packages require a consistent manual curation effort as data is scattered across different resources (10–12).”
- DREADDs for Neuroscientists (2016, background): “…chemical biology platforms that allow for the unbiased assessment of on- and off-target pharmacologies of chemical actuators across the GPCR-ome (Kroeze et al., 2015), kinome (Elkins et al., 2015), and other targets (Arrowsmith et al., 2015) are key to validating the specificity of DREADD ligands.”
- Open Targets Platform: new developments and updates two years on (2018, background): “We also link to a set of the 215 high-quality chemical probes (20,21) available for 188 different targets, giving access to reagents and assays to aid in vitro and/or in vivo investigation of phenotype and mechanism of a target.”