Liver X receptors as integrators of metabolic and inflammatory signaling.

By N. Zelcer, P. Tontonoz. Journal of Clinical Investigation, 2006

956 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/7e290a06d654ed7c654cc921bf3a0c7b6a3bbbf6

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Citations in the corpus

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR (2012, background): “The role of LXRs as modulators of inflammation and immunity has been reviewed elsewher”
Liver lipid metabolism. (2008, background): “In addition to their role in cholesterol metabolism, LXRs are also key regulators of hepatic lipogenesis through the upregulation of the master regulator of hepatic lipogenesis, SREBP-1c, as well as induction of FAS and acyl-CoA carboxylase (Zelcer and Tontonoz, 2006).”
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, neutral): “Furthermore, LXR regulates the expression of cholesterol and lipid transporting proteins, such as ABCG5 and ABCG8 in the intestine or ABCG1, ABCA1 and apolipoproteins E and C in macrophages (Yu et al. 2002; Zelcer and Tontonoz 2006).”
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population (2008, background): “An associated region on chromosome 11 includes NR1H3 , also termed LXRA , a transcriptional regulator of cholesterol metabolis”
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. (2007, background): “Recent studies have characterized LXRs as regulators of innate immunity and inflammatory signaling in macrophages (Zelcer and Tontonoz, 2006).”
ApoE promotes the proteolytic degradation of Abeta. (2008, background): “These recent studies also found that LXRs inhibited the microglia-mediated inflammatory response and inflammatory gene expression, owing to their ability to functionally inactivate the promoters of proinflammatory genes (Zelcer and Tontonoz, 2006).”
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis (2006, background): “? Or with the liver X receptors ( LXR ) and their associated ligands and immune function”
Integration of metabolism and inflammation by lipid-activated nuclear receptors (2008, background): “Recently, it has become increasingly clear that inflammation that is mediated by tissue-resident macrophages is an essential component of many metabolic, endocrine and cardiovascular disorder”
The Metabolic Signature of Macrophage Responses (2019, background): “In contrast, M2 macrophages are characterized by LXR activation, which regulates cholesterol homeostasis and lipid synthesis (154).”