Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.

By H.E. Xu, M. Lambert, V. Montana, D. Parks, S. Blanchard, P. Brown, D. Sternbach, J. Lehmann, G. Wisely, T. Willson and 2 more. Molecules and Cells, 2000

1,180 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b5dfb4c500320e8d7e7d9c2eb2a7bf89551b19d1

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Citations in the corpus

Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors. (2007, background): “The ligandbinding pocket of PPARb/d is much larger than the pockets of other nuclear receptors (Xu et al., 1999).”
Peroxisome Proliferator-Activated Receptor Alpha Target Genes (2010, background): “The LBD harbors the ligand-binding pocket crucial for dimerization with RXR and contains the activating function-2 involved in physical interactions with coregulatory proteins [7, 29, 30].”
Integrated physiology and systems biology of PPARα (2014, background): “The large hydrophobic binding cavity allows PPARs to interact with a variety of structurally related and unrelated compounds [151].”
Mechanisms of phthalate ester toxicity in the female reproductive system. (2002, background): “fatty acids, mediate their effects at micromolar concentrations (Willson et al. 2001; Xu et al. 1999).”
A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation (2010, background): “For example, free fatty acids are activating ligands for peroxisome proliferator-activated receptors [PPARs (Krey et al. 1997; Forman et al. 1997; Murakami et al. 1999; Xu et al. 1999)], a subclass of the nuclear hormone receptor family.”
Regulation of energy metabolism by long-chain fatty acids. (2014, methodology): “Because of this large binding pocket, short and medium chain fatty acids possess low affinity, and thus are unable to activate PPARs [17,18,20].”
The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes (2000, background): “A diverse group of compounds can act as activating ligands for PPARa including several prostaglandin derivatives, eicosanoids, and long-chain unsaturated fatty acids (8, 18, 39).”
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “The naturally occurring ligands for the PPAR are fatty acids and eicosanoids, which are active at micromolar concentrations (283, 284, 290, 291).”
Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research (2020, background): “The ability of various PFAS to interact with and modify lipid metabolism is, however, an intriguing hypothesis (Xu et al. 1999; Jones et al. 2003; Andersen et al. 2007; Tan et al. 2013; Pouwer et al. 2019).”
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. (2008, background): “Since a variety of fatty acids and fatty acid metabolites can bind and activate these receptors (Xu et al., 1999), PPARs act as fatty acid sensors to alter metabolic pathways in response to changes in fuel availability (Kliewer et al., 2001).”