St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.
By L. Moore, B. Goodwin, Stacey A. Jones, G. Wisely, C. Serabjit-Singh, T. Willson, J. Collins, S. Kliewer. Proceedings of the National Academy of Sciences of the United States of America, 2000
927 citations recorded by the source corpus.
Subfields: Oncology, Pediatrics, Perinatology and Child Health, Pharmacology
View Paper: https://www.semanticscholar.org/paper/16dc8d1a73f62d7943cfb442a2318335904b2716
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Citations in the corpus
- The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. (2002, background): “Hyperforin bound to human PXR with an IC50 value of approximately 20 nm and induced CYP3A4 expression in primary cultures of human hepatocytes (118).”
- St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties (2001, background): “…been shown that treatment of human hepatocytes with hypericum extract and hyperforin results in a marked induction of CYP3A4 expression, and that hyperforin is a potent ligand for the pregnane X receptor, a nuclear receptor that regulates the expression of CYP3A4 monooxygenase (Moore et al 2000).”
- Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism (2002, background): “A number of drugs, and herbal medications such as St John’sWort, that enhance the activity of this isoform[218,219] are likely to induce the metabolism of PPIs and decrease the effective concentration in plasma.”
- The Influence of Plant Secondary Metabolites on the Nutritional Ecology of Herbivorous Terrestrial Vertebrates (2005, background): “Both P-gp and CYP3A can be induced by PSMs that bind the nuclear pregnane X receptor (PXR) of liver and intestinal cells (Dresser et al. 2003, Kullak-Ublick & Becker 2003, Moore et al. 2000).”