ApoE promotes the proteolytic degradation of Abeta.

By Qingguang Jiang, C.Y. Daniel Lee, Shweta Mandrekar, B. Wilkinson, Paige E. Cramer, N. Zelcer, K. Mann, B. Lamb, T. Willson, Jon L. Collins and 7 more. Neuron, 2008

921 citations recorded by the source corpus.

Subfields: Oncology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/a40bf22a2563478c5fb2cafe3743133bb130a8a2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. G. Bu
2. D. Holtzman

In Physiology

1. D. Holtzman
2. J. Long
3. J. Herz
4. A. Goate
5. G. Bu
6. John C. Morris
7. John Hardy
8. Jungsu Kim

In Surgery

1. D. Holtzman
2. J. Herz

Citations in the corpus

• Human apoE isoforms differentially regulate brain amyloid-β peptide clearance (2011, positive): “mediated degradation of Aβ42 within microglia, with apoE4 being the least effective in facilitating Aβ degradation compared to apoE2 or apoE3 (60).”
• Genetics of Alzheimer's Disease (2013, result): “In contrast to the mitochondrial cascade hypothesis, in the amyloid cascade hypothesis, changes such as A𝛽 aggregation and tau phosphorylation happen first and lead to the dysfunction of mitochondria [10, 13, 17].”
• Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease (2010, background): “The lipidation state of APOE is critical to its ability to transport Ab across the BBB, APOE4 being associated with the least efficient transport [35].”
• Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. (2012, background): “Data from in vitro studies support the idea that apoE facilitates the binding and internalization of soluble Ab by cells or its clearance via enzymes such as neprilysn (Beffert et al. 1998; Yang et al. 1999; Cole and Ard 2000; Koistinaho et al. 2004; Jiang et al. 2008).”
• The Role of Apolipoprotein E in Alzheimer’s Disease (2009, positive): “Two in vitro studies have also demonstrated that apoE can facilitate the cellular degradation of Ab (Jiang et al., 2008; Koistinaho et al., 2004).”
• Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy (2009, background): “Interestingly, APOE promotes Aβ degradation by neprilysin and IDE, with APOE3 functioning more efficiently than APOE4 (Ref”
• Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019, positive): “ApoE is also required for microglial intracellular endolytic degradation of Aβ by neprilysin and insulin-degrading enzyme (Jiang et al., 2008).”
• The role of microglia in amyloid clearance from the AD brain (2010, background): “Among these proteases, NEP and IDE are the principle intracellular and extracellular enzymes for Aβ degradation by microglia and other cell types, respectively (Iwata et al. 2000; Jiang et al. 2008; Kurochkin and Goto 1994; Mukherjee and Hersh 2002).”