Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.
By S. Ogawa, J. Lozach, C. Benner, G. Pascual, R. Tangirala, S. Westin, Alexander Hoffmann, Shankar Subramaniam, M. David, Michael G. Rosenfeld and 1 more. Cell, 2005
687 citations recorded by the source corpus.
Subfields: Cancer Research, Genetics, Immunology
View Paper: https://www.semanticscholar.org/paper/58781ba075554620e175f15a6d76c6fb515bfcf2
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In Cancer Research
- N. Perkins
- R. Medzhitov
- David Baltimore
- Alexander Hoffmann
- P. Tontonoz
- Christopher K. Glass
- G. Natoli
- E. Janssen
In Genetics
In Immunology
- R. Medzhitov
- N. Perkins
- T. Horng
- David Baltimore
- P. Tontonoz
- Kaoru Saijo
- Christopher K. Glass
- Alexander Hoffmann
Citations in the corpus
- Regulation of innate immune responses in the brain (2009, background): “Other mechanisms of glucocorticoid-mediated immune suppression that have been described recently include the inhibition of p38 MAP kinase through the phosphatase MKP1, the interaction of activated glucocorticoid receptors with the NF-κB p65–IFN regulatory factor 3 (IRF3) complex and inhibition of th”
- Circuitry of nuclear factor κB signaling (2006, background): “Interestingly, many of these IRF3-dependent promoters were found to be sensitive to repression by GR when activated by NF-kB-inducing stimuli (88).”
- Transcriptional control of the inflammatory response (2009, background): “In addition, p65 and IRF3 were shown to interact, and the glucocorticoid receptor could disrupt this bindin”
- Integration of metabolism and inflammation by lipid-activated nuclear receptors (2008, background): “We and others have shown that activation of LXRs antagonizes inflammatory gene expression downstream of TLR4 signalling, IL-1β-mediated signalling and TNF-α-mediated signallin”
- Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. (2007, background): “A General SUMO/NCoR Transrepression Mechanism Many nuclear receptors can act in trans to repress inflammatory responses, with recent studies indicating that ligand-dependent repression of inflammatory target genes occurs in a gene and signal-specific manner (Ogawa et al., 2005).”
- Integrating cell-signalling pathways with NF-κB and IKK function (2007, background): “Direct interaction with NRs can result in sequestration of NF-κB, which inhibits IRF3-dependent promoters at which RelA functions as a transcriptional co-activato”
- Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006, background): “Another intriguing aspect that links these three receptors is their profound anti-inflammatory actions, implicating the existence of an important evolutionary link between the regulation of innate immunity and nutrient metabolism (Ogawa et al., 2005).”