Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

By C. Sinal, M. Tohkin, M. Miyata, J. Ward, G. Lambert, F. Gonzalez. Cell, 2000

1,769 citations recorded by the source corpus.

Subfields: Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/6f64d150d27f686c86fe8d648631d74cf4b2adbb

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In Oncology

1. J. Y. Chiang
2. P. Tontonoz
3. Tiangang Li
4. A. Calkin
5. D. Mangelsdorf
6. P. Edwards
7. Johan Auwerx
8. David S. Wishart

In Surgery

1. J. Y. Chiang
2. P. Tontonoz
3. A. Calkin
4. D. Mangelsdorf
5. Tiangang Li
6. P. Edwards
7. Johan Auwerx
8. Bart Staels

Citations in the corpus

• Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. (2004, background): “FXR–/– mice show decreased basal expression of SHP and have increased serum and hepatic TG levels (31).”
• Bile Acids and the Gut Microbiome (2014, background): “Bile acid synthesis is self-regulated by a feedback loop involving both liver and intestinal expression and activation of the nuclear receptor FXR [22].”
• Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. (2004, neutral): “FXRdeficient mice have increased serum TG levels (201), and FXR has been shown to regulate the hepatic expression of apoC-II and apoE (202, 203), both of which are decreased during the APR (85, 184).”
• Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR (2012, background): “Indeed, FXR-deficient mice have greatly aided in studying the role of FXR in metabolis”
• A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. (2000, background): “An LRH-1-responsive region of livers of mice lacking FXR ( Sinal et al., 2000 ).”
• Energy Metabolism in the Liver (2014, neutral): “FXR knockout mice have higher levels of TAG both in the circulation and in the liver (247).”
• Pleiotropic Roles of Bile Acids in Metabolism (2013, background): “(1) Lipoprotein Metabolism The original characterization of Fxr–/– mice suggested that FXR also controls lipid metabolism, as these mice had elevated hepatic lipids as well as increased plasma triglycerides, cholesterol, free fatty acids, and lipoproteins (VLDL and LDL) (Sinal et al., 2000).”
• Farnesoid X receptor is essential for normal glucose homeostasis. (2006, methodology): “the mice was performed as described previously (5, 11).”