An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

By W. Xie, A. Radomińska-Pandya, Yanhong Shi, C. M. Simon, Michael C. Nelson, E.S. Ong, D. Waxman, R. Evans. Proceedings of the National Academy of Sciences of the United States of America, 2001

793 citations recorded by the source corpus.

Subfields: Oncology, Pediatrics, Perinatology and Child Health, Pharmacology

View Paper: https://www.semanticscholar.org/paper/227fe60e8f1bd34ed016405701034d9cd4011675

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. J. Y. Chiang
2. Tiangang Li
3. Christoph Borner
4. Johan Auwerx
5. David S. Wishart

In Pediatrics, Perinatology and Child Health

1. J. Y. Chiang

In Pharmacology

1. B. Goodwin
2. S. Kliewer
3. T. Willson

Citations in the corpus

• Induction of phase I, II and III drug metabolism/transport by xenobiotics (2005, background): “Both CAR and PXR can regulate the CYP3A and CYP2B gene expression by their specific ligands in CV-1 cells as well as in hepatocytes (Wang et aL, 2003; Wang and LeCluyse, 2003; Xie et aL, 2000b, 2001 ).”
• Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “In this respect, it is important to take into account experimental conditions that led to the classification of FXR ligands (see Table 1), and to keep in mind that BAs are promiscuous ligands; BAs also activate VDR [LCA, LCA-acetate (1, 189)] and PXR [LCA (299, 347)] or repress CAR (206).”
• Targeting bile-acid signalling for metabolic diseases (2008, background): “In fact, the hydrophobic bile acid LCA and its derivatives are potent agonist ligands for pregnane X receptor (PXR; also known as NR1I2”
• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. (2002, background): “1), which is formed in the intestine by the bacterial 7 -hydroxylation of chenodeoxycholic acid, and its 3-keto metabolite were both efficacious activators of the mouse and human PXR (16, 131).”
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “…including FXR (Kalaany and Mangelsdorf 2006; Lefebvre et al. 2009; Makishima et al. 1999; Parks et al. 1999; Teng and PiquetteMiller 2008), PXR (Staudinger et al. 2001; Xie et al. 2001) and the vitamin D receptor (VDR, NR1I1) (Gascon-Barre et al. 2003; Han and Chiang 2009; Makishima et al. 2002).”
• Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. (2002, background): “…be regulated by endogenous substances, such as steroids (Forman et al., 1998; Kliewer et al., 1998; Moore et al., 2000b; Staudinger et al., 2001; Xie et al., 2001), these nuclear receptors may also be important components in the body’s defenses against chemicals that are produced during periods…”
• Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “Kodama S, Koike C, Negishi M, and Yamamoto Y (2004) Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.”
• Bile acids: regulation of synthesis (2009, background): “detoxification of bile acids, drugs, and xenobiotics (22, 24, 25).”