Hozumi Motohashi

Molecular Biology · 2003–2018

A researcher in the Science corpus: 11 papers; trusts 12 researchers and is trusted by 11 researchers here, as inferred from the citation graph.

Subfields

• Molecular Biology — 177 citations into it; #4,003 of 17,773 by trust here, #1,510 by citations
• Plant Science — 21 citations into it
• Health, Toxicology and Mutagenesis — 8 citations into it; #437 of 1,398 by trust here, #198 by citations

Whom Hozumi Motohashi trusts overall

Their strongest outbound trust, strongest first, inferred from their citations.

1. K. Itoh
2. Donna D. Zhang
3. N. Wakabayashi
4. K. I. Tong
5. Masayuki Yamamoto
6. A. Kobayashi
7. A. Dinkova-Kostova

Who trusts Hozumi Motohashi overall

1. Gerasimos P. Sykiotis
2. Wenge Li
3. Q. Ma
4. A. Dinkova-Kostova
5. Masayuki Yamamoto
6. K. Taguchi
7. D. Bohmann
8. Melba C. Jaramillo
9. Takafumi Suzuki
10. J. Hayes

Papers from Hozumi Motohashi's perspective

Ordered by how strongly the researchers Hozumi Motohashi trusts endorse each paper. Same corpus, a different order for every researcher.

1. Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers (Proceedings of the National Academy of Sciences of the United States of America)
2. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. (Annual Review of Pharmacology and Toxicology)
3. BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase (Molecular and Cellular Biology)
4. Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles (Genes to Cells)
5. Nrf2-Keap1 defines a physiologically important stress response mechanism. (Trends in Molecular Medicine)
6. Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress (Molecular and Cellular Biology)
7. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. (Free Radical Biology & Medicine)
8. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. (Advances in Enzyme Regulation)
9. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy (Proceedings of the National Academy of Sciences of the United States of America)
10. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. (Cancer Research)

Their papers

• The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 (2010) — 2,354 citations
• Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013) — 1,109 citations
• Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. (2012) — 1,346 citations
• Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation (2003) — 879 citations
• A promoter-level mammalian expression atlas (2014) — 1,941 citations
• Nrf2-Keap1 defines a physiologically important stress response mechanism. (2004) — 1,729 citations
• Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution (2011) — 1,466 citations
• The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. (2018) — 1,708 citations
• Toward clinical application of the Keap1-Nrf2 pathway. (2013) — 665 citations
• Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription (2016) — 1,683 citations
• Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling (2014) — 823 citations