Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles.

By K. Itoh, K. I. Tong, Masayuki Yamamoto. Free Radical Biology & Medicine, 2004

874 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f9f1d5f39ed6c90b4949f188480d5446abbbcbe4

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Citations in the corpus

Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. (2008, background): “Oxidative stresses or electrophilic xenobiotics abolish the inhibition of Nrf2 by Keap1 (Itoh et al., 2004).”
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex (2004, background): “3 g, lanes 2 to 5), and Cul3(1-380) (from 0.”
Glutathione: Overview of its protective roles, measurement, and biosynthesis (2008, background): “The EpRE elements bind proteins members of the Nrf family, Jun family and small Maf family (Venugopal and Jaiswal, 1998; Kong et al., 2001; Moran et al., 2002; Itoh et al., 2004).”
The changing faces of glutathione, a cellular protagonist. (2003, background): “The inhibitory subunit of NE2FL2, Keap1, is a cysteine-rich protein that serves as a redox sensor and can bind to p62 and be degraded by autophagic activity.”
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution (2011, background): “In the presence of electrophiles or ROS, Nrf2 degradation ceases, stabilized Nrf2 accumulates in nuclei, heterodimerizes with small Maf proteins and activates target genes for cytoprotection through antioxidant response element (ARE) ⁄ electrophile response element (EpRE) (Itoh et al. 2004).”
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. (2006, background): “Both cadmium and heme stimulate ho-1 by a dual mechanism involving the stabilization of Nrf2 by inhibiting its degradation via the ubiquitin-proteasomal pathway, and in parallel, the stimulation of the nuclear export of Bach1 (21, 633).”
Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model (2006, background): “The induction of these cytoprotective genes is regulated at the transcriptional level by a specific cis-acting element, the antioxidant/electrophile response element (ARE/EpRE) found in the promoter regions of these genes (21, 39, 40).”
Glutathione: new roles in redox signaling for an old antioxidant (2014, background): “The inhibitory subunit of NE2FL2, Keap1, is a cysteine-rich protein that serves as a redox sensor and can bind to p62 and be degraded by autophagic activity.”