Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species.

By Makoto Kobayashi, Masayuki Yamamoto. Advances in Enzyme Regulation, 2006

832 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/a53bc4ad669436ae4e3e25491f6409099ce96d0f

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In Molecular Biology

Citations in the corpus

ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis (2007, background): “KeaP1 Cys273 and Cys288, which are among the few reactive Cys residues that have been identified in this protein, are indeed crucial for both zinc coordination and nRF2 degradation 96,98,99 .”
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism (2016, background): “This is a relatively rapid event, with Nrf2 exhibiting a short half-life of approximately 20 min [6].”
The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds (2008, background): “Nrf2 is a transcription factor that transactivates cytoprotective genes through a common DNA regulatory element, called the antioxidant response element or electrophile response element (18, 24).”
Nrf2:INrf2(Keap1) Signaling in Oxidative Stress (2009, neutral): “Keap1 has three additional domains/regions: the Nterminal region, the intervening region, and the C-terminal region [8].”
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer (2007, background): “In response to oxidative stress, the transcription factor NRF2 , normally sequestered by its inhibitor KEAP1, is released and then activates an antioxidant response element (ARE) on the promoter of phase 2-response gene”
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, neutral): “This reaction leads to conformational changes in Keap1 that abrogate its ability to repress Nrf2, ultimately resulting in Nrf2 stabilization, binding to the ARE and recruitment, the basal transcriptional machinery to activate transcription of cytoprotective genes (200, 237, 315).”
SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner (2011, background): “The interaction between Nrf2 and Keap1 occurs via a “two-site tethering” process, otherwise called the “hinge and latch” mechanism.”
Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “The Nrf2-Keap1 system has been observed in virtually all vertebrates, suggesting that Nrf2 is a highly conserved cellular defense mechanism (Kobayashi and Yamamoto 2006).”
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. (2008, neutral): “genes [5,6].”
Regulation of Nrf2 – An update (2013, background): “The battery of cytoprotective proteins also include drug transporters that play important role in drugs intake and efflux [36–40]; antiapoptotic proteins Bcl-2 and Bcl-xL that prevent apoptotic cell death and promote cell survival [41–43]; and proteasomes that remove oxidized/damaged proteins [44].”
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 (2010, background): “As a result, Nrf2 becomes stabilized and translocates to the nucleus to induce the transcription of numerous cytoprotective genes through its heterodimerization with small Maf protein”
Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals (2008, neutral): “Detailed mechanisms underlying the regulation of Nrf2 by Keap1-Cul3 complex in intact cells as well as in those under stress have been reviewed elsewhere [11], [40], [41] and are beyond the scope of this article.”
Redox Regulation of Cell Survival (2008, neutral): “NF-E2–related factor 2 (Nrf2) is a member of p45 NF-E2–related proteins (p45 NF-E2, Nrf1, Nrf2, and Nrf3 (162, 163).”