K. Itoh

Molecular Biology · 2000–2006

A researcher in the Science corpus: 11 papers; trusts 1 researcher and is trusted by 24 researchers here, as inferred from the citation graph.

Subfields

Molecular Biology — 43 citations into it; #1,454 of 17,773 by trust here, #1,025 by citations

Whom K. Itoh trusts overall

Their strongest outbound trust, strongest first, inferred from their citations.

Who trusts K. Itoh overall

Papers from K. Itoh's perspective

Ordered by how strongly the researchers K. Itoh trusts endorse each paper. Same corpus, a different order for every researcher.

Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter (Molecular and Cellular Biology)
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. (Cell)
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2 (Molecular and Cellular Biology)
Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex (Nature)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants (Proceedings of the National Academy of Sciences of the United States of America)
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers (Proceedings of the National Academy of Sciences of the United States of America)
BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase (Molecular and Cellular Biology)
Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. (Free Radical Biology & Medicine)
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice (Proceedings of the National Academy of Sciences of the United States of America)
Nrf2-Keap1 defines a physiologically important stress response mechanism. (Trends in Molecular Medicine)

Their papers

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages* (2000) — 1,517 citations
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants (2002) — 1,958 citations
Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression* (2003) — 1,150 citations
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice (2001) — 1,185 citations
Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles (2003) — 852 citations
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation (2003) — 879 citations
Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model (2006) — 735 citations
Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. (2004) — 874 citations
Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter (2002) — 600 citations
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. (2001) — 743 citations
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. (2001) — 701 citations