Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

By K. Taguchi, Hozumi Motohashi, Masayuki Yamamoto. Genes to Cells, 2011

1,466 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/34c1b74d7699ce9b3b9a4666fe322835851078ad

How researchers see this paper

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In Molecular Biology

1. Q. Ma
2. Masayuki Yamamoto
3. Hozumi Motohashi
4. M. Komatsu
5. Yu Chen
6. Longqin Hu
7. S. Magesh
8. K. Guan

In Plant Science

1. Q. Ma
2. Hozumi Motohashi
3. K. Guan
4. Masayuki Yamamoto

Citations in the corpus

• The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer (2013, background): “The exact mechanism whereby cysteine modifications in Keap1 lead to Nrf2 activation is not known, but the two prevailing but not mutually exclusive models are (1) the ‘‘hinge and latch’’ model, in which Keap1 modifications in thiol residues residing in the IVR of Keap1 disrupt the interaction with N”
• Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. (2012, background): “Moreover, KEAP1 and NRF2 have been implicated in tumor development (Taguchi et al. 2011), although their contributions to oncogenesis in FH mutant cancer still require further exploration.”
• An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation (2020, background): “When specific thiol residues are modified by electrophiles, the DLG motif dissociates from Keap1 causing a disruption in the alignment of Nrf2 lysine residues that ultimately prevent its ubiquitination (Figure 2) [23,27].”
• Role of nrf2 in oxidative stress and toxicity. (2013, background): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript The mechanism by which Keap1 interacts with Nrf2 and direct Nrf2 ubiquitination was revealed from structural resolution of Keap1 and Nrf2.”
• Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents (2012, background): “22 Other triterpenoid natural products, such as avicin D (29)190 and gedunin (30),175 were also shown to increase the expression of certain cytoprotective enzymes via Nrf2 activation.”
• Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013, background): “The Keap1-Nrf2 system is currently recognized as one of the major cellular defense mechanisms against oxidative and electrophilic stresses (Hayes and McMahon, 2009; Taguchi et al., 2011; Villeneuve et al., 2010).”