Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

By Y. Mitsuishi, K. Taguchi, Y. Kawatani, T. Shibata, T. Nukiwa, H. Aburatani, Masayuki Yamamoto, Hozumi Motohashi. Cancer Cell, 2012

1,346 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/280f3f56ddaa915842258eabcbeb792646ef42a7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Donna D. Zhang
2. Masayuki Yamamoto
3. A. Dinkova-Kostova
4. A. Abramov
5. T. Yoshimori
6. Lucas B. Sullivan
7. Navdeep S. Chandel
8. E. Kurutaş

In Molecular Biology

1. A. Dinkova-Kostova
2. D. Tang
3. Masayuki Yamamoto
4. Donna D. Zhang
5. R. Kang
6. J. Hayes
7. Q. Ma
8. Hozumi Motohashi

Citations in the corpus

• Oxidative Stress in Cancer (2020, background): “Studies of Keap1FA/− mice have revealed that constitutive upregulation of Nrf2 increases proliferation of forestomach epithelium, but not cancer (Mitsuishi et al., 2012), and that Nrf2-mediated maximal transactivation of G6pd, Pgd, and Me1 requires activation of the PI3K-Akt signaling pathway, which”
• Role of nrf2 in oxidative stress and toxicity. (2013, background): “Nrf2 promotes aggressive proliferation of cancer cells by reinforcing the metabolic programming triggered by proliferative signals; in this scenario, Nrf2 redirects glucose and glutamine into anabolic pathways to support aggressive proliferation (85).”
• Mitochondrial reactive oxygen species and cancer (2014, background): “Activation of NRF2 increases synthesis of anabolic enzymes and supports tumor growth by increasing production of NADPH increasing and purine biosynthesis [64].”
• Oncogenic Signaling Pathways in The Cancer Genome Atlas (2018, background): “PI3K pathway activation promotes NRF2 accumulation, which, in turn, mediates metabolic pathways required to sustain cell proliferation and protection from reactive oxidative species (Mitsuishi et al., 2012).”
• Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013, background): “, 2008) and repressed the proliferation of cancer cell lines in which Nrf2 was constitutively activated (Mitsuishi et al., 2012).”
• The Roles of NRF2 in Modulating Cellular Iron Homeostasis (2017, background): “For example, NRF2 can upregulate expression of genes in the pentose phosphate pathway, pyruvate cycling (malic enzyme), and folate metabolism (MTHFD2) (100, 165), which can generate cellular NADPH (28, 153).”