Toward clinical application of the Keap1-Nrf2 pathway.

By Takafumi Suzuki, Hozumi Motohashi, Masayuki Yamamoto. TIPS - Trends in Pharmacological Sciences, 2013

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Activation of the p62-Keap1-NRF2 Pathway Protects against Ferroptosis in Hepatocellular Carcinoma Cells (2015, background): “MafG, recruitment of transcriptional coactivators, and subsequent binding to antioxidant response elements of target genes.(6) It is clear that NRF2 plays a dual role in”
The emerging role of Nrf2 in mitochondrial function (2015, background): “…and the newly synthesized Nrf2 accumulates and translocates to the nucleus. to the nucleus (Fig.1B), where it forms a heterodimer with a small Maf protein; binds to antioxidant-response elements, the upstream regulatory regions of its target genes; and initiates transcription [14 – 16].”
Metallothionein-1G Facilitates Sorafenib Resistance through Inhibition of Ferroptosis (2016, background): “, oxidative stress), inducers modify the Kelch-like ECHassociated protein 1 cysteines or expression leading to NRF2 stabilization.((34)) We previously demonstrated that sorafenib prevented NRF2 degradation and enhanced subsequent NRF2 nuclear accumulation through inactivation of Kelch-like ECH-assoc”