BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase

By M. Furukawa, Y. Xiong. Molecular and Cellular Biology, 2005

751 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/27c5fca6bcf11ae8e76b0f1308405b9844d39f34

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In Molecular Biology

Citations in the corpus

NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. (2008, positive): “1-p65 siRNA vector [39], myc-p65, p65(S205A), p65(S276A), p65(S281A)[40], p65(S536A) [41], p65 truncated mutants [42], V5-MafK [43], Gal4-Nrf2(TAD, 1–317aa) [44], Nrf2(E82G) [45], RSV-E1A, HA-CBP [46], GST-CBP(116-738) [47], PKAc(WT), PKAc(K72H) [48], HDAC4/5 [49], pNF-κB-luciferase was obtained fro”
Redox Regulation in Photosynthetic Organisms: Signaling, Acclimation, and Practical Implications (2009, neutral): “The global wheel of oxidation–reduction (redox) systems by which present-day living organisms store and release energy was set in motion by the evolution of oxygenic photosynthesis (7).”
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism (2011, background): “Moreover, no mutation was found in either Nrf2 or Keap1 in HeLa cells (7, 25).”
Molecular Mechanisms of Nrf2-Mediated Antioxidant Response (2009, background): “The BTB domain [36-39] and probably part of the IVR domain [39] bind to the ubiquitination catalytic complex.”
The emerging role of the Nrf2–Keap1 signaling pathway in cancer (2013, background): “The ETGE and DLG motifs interact with Keap1, which is a substrate adaptor protein for the Cullin 3 (Cul3)dependent E3 ubiquitin ligase complex that represses Nrf2 by promoting its ubiquitination and subsequent proteasomal degradation (Cullinan et al. 2004; Kobayashi et al. 2004; Zhang et al. 2004; F”
Nrf2:INrf2(Keap1) Signaling in Oxidative Stress (2009, neutral): “Under normal cellular conditions, the cytosolic INrf2/Cul3/Rbx1 complex is constantly degrading Nrf2.”
Transcriptional Regulation by Nrf2 (2017, background): “Under unstressed conditions, Nrf2 is constantly targeted for proteasomal degradation by the Keap1/Cul3 E3 ubiquitin ligase complex (37, 60, 80, 192).”
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution (2011, background): “…et al. 2003; Xu et al. 2003), it did not take long for researchers to discover that Keap1, a BTB protein, is a component of the Cul3-based ubiquitin E3 ligase complex and mediates polyubiquitination of Nrf2 (Cullinan et al. 2004; Kobayashi et al. 2004; Zhang et al. 2004; Furukawa & Xiong 2005).”