Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.

By T. Inagaki, Mihwa Choi, A. Moschetta, Li Peng, C. Cummins, J. McDonald, G. Luo, Stacey A. Jones, B. Goodwin, J. Richardson and 4 more. Cell Metabolism, 2005

1,800 citations recorded by the source corpus.

Subfields: Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/afc97fc5c7189387cb3bb534474599a2f20dd1e3

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Citations in the corpus

Targeting bile-acid signalling for metabolic diseases (2008, background): “, and of the secreted growth factor, fibroblast growth factor 19 ( FGF19 ), which is known as Fgf15 in the mous”
Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. (2013, background): “A BA-induced mechanism promoting insulin sensitivity relies on FXR-mediated production of fibroblast growth factor (FGF) 19 (and its mouse orthologue FGF15), an enterokine released by the ileal enterocyte that activates the cognate receptor FGFR4 in the liver to suppress CYP7A1/CYP8B1 expression, th”
Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “As previously reported for CYP7A1 (129), FXRmediated repression of PON1 involves the induction of FGF-19, its subsequent binding to FGFR4, and activation of the JNK pathway (101, 285).”
FGF/FGFR signaling in health and disease (2020, background): “FGF15 is highly expressed in the ileum, jejunum, and duodenum of adult mice.(532,533) FGF19 is expressed in human ileum and gallbladder epithelial cells,(534,535) and is not detected normally in human liver.”
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. (2011, background): “The phenotypes of Klotho knockout mice overlap those of Fgfr4 knockout mice and Fgf15/19 knockout mice (28, 29).”
Bile Acids and the Gut Microbiome (2014, background): “Intestinal FXR appears to regulate hepatic cholesterol 7a-hydroxylase (CYP7A1), the ratelimiting enzyme in bile acid synthesis, through a fibroblast growth factor 15 (FGF-15/19)-dependent mechanism [23,24].”
Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans (2008, background): “FGF19 is expressed by the intestinal epithelium and is involved in regulating hepatic bile acids synthesis (11) and adiposity (12).”
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response (2009, background): “Third, FGF21 causes growth hormone resistance and blunts growth in mice, a phenomenon that occurs during starvation (34).”
The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity1 (2009, background): “and fibroblast growth factor 15 (17), with both genes regulating”
Bile acids: regulation of synthesis (2009, background): “A subsequent study has demonstrated that FXR induces FGF15, a mouse ortholog of FGF19 in mouse intestine, and the expression of FGF15 mRNA is inversely correlated to CYP7a1 mRNA expression levels in mouse liver (127).”