FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

By Matthew J. Potthoff, T. Inagaki, S. Satapati, Xunshan Ding, T. He, R. Goetz, M. Mohammadi, B. Finck, D. Mangelsdorf, S. Kliewer and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2009

730 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/d5ff8576f04cce96636d37bbeae79c06f5c6361e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. N. Itoh
2. B. K. Pedersen
3. Manabu T. Nakamura
4. J. Loor
5. S. Kersten
6. M. Laplante
7. David M. Sabatini

In Surgery

1. B. K. Pedersen
2. S. Kersten

Citations in the corpus

• Muscles and their myokines (2011, background): “Mice lacking FGF21 fail to fully induce PGC-1a expression in response to a prolonged fast and have impaired gluconeogenesis and ketogenesis (Potthoff et al., 2009).”
• Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. (2013, background): “In vivo administration of FGF21 enhances hepatic fatty acid oxidation and tricarboxylic acid cycle flux via inducing the expression of PGC1a and its downstream target genes (Potthoff et al., 2009).”
• Regulation of energy metabolism by long-chain fatty acids. (2014, background): “FGF21 KO mice exhibited decreased fasting blood glucose, liver b-oxidation, ketogenesis and gluconeogenesis, demonstrating that FGF21 in part mediates the effects of PPARa during the adaptation to fasting [101].”
• FGF/FGFR signaling in health and disease (2020, background): “FGF21 knockout mice fail to induce PGC-1α expression and have impaired gluconeogenesis and ketogenesis in response to a prolonged fast.(559) However, the mechanisms for the regulation of FGF21 on liver metabolism need to be further explored.”
• Integrated physiology and systems biology of PPARα (2014, background): “How FGF21 induces these pathways remains unclear but its effects are thus clearly distinct from direct gene regulation by PPARa and likely involve extrahepatic tissues [240,241].”
• Energy Metabolism in the Liver (2014, neutral): “2B), TCA flux, and ketogenesis (212).”