Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.

By T. Inagaki, A. Moschetta, Youn-Kyoung Lee, Li Peng, Guixiang Zhao, M. Downes, R. Yu, J. Shelton, J. Richardson, J. Repa and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2006

1,117 citations recorded by the source corpus.

Subfields: Molecular Medicine, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/524561a99d7089bb1508392711aa3cdba334bdb3

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Citations in the corpus

Pathological bacterial translocation in liver cirrhosis. (2014, background): “Abbreviations: AMP, antimicrobial peptides; APC, antigen-presenting cell; BDL, bile duct ligation; BT, bacterial translocation; CCl4, carbon-tetrachloride; DC, dendritic cell; FxR, Farnesoid X receptor; GALT, gut-associated lymphoid tissue; GI, gastrointestinal; GNB, gram-negative bacteria; HE, hepa”
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism. (2016, positive): “, iNOS and IL-18) that affect the gut microbiota via the immune system (Inagaki et al., 2006).”
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006, background): “The FXR/ SHP/LRH-1 axis has also been implicated in regulation of lipid and glucose metabolism as a consequence of nutrient intake (Duran-Sandoval et al., 2005; Watanabe et al., 2004; Zhang et al., 2004) and in preserving innate immunity in the gut (Inagaki et al., 2006).”
Role of bile acids and bile acid receptors in metabolic regulation. (2009, neutral): “epithelial barrier function (130), underlining the complex-”
The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity1 (2009, background): “(19) have shown that mice lacking FXR have increased ileal levels of bacteria and a compromised epithelial barrier.”
Bile Acids and the Gut Microbiome (2014, background): “It is clear that bile acids have both direct antimicrobial effects on gut microbes [10], and indirect effects through farnesoid X receptor (FXR)-induced antimicrobial peptides [11].”
Targeting bile-acid signalling for metabolic diseases (2008, background): “Furthermore, as bile acids are bacteriostatic in the intestine, FXR-α activation has been shown to be enteroprotective, resulting in the prevention of bacterial overgrowth and subsequent epithelial deterioration and bacterial translocatio”
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease (2017, background): “Interestingly, the primary bile acid chenodeoxycholic acid can also have an indirect protective function by activating innate defenses in the small intestine via its receptor, FXR.38”
Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “Bile acids also play a protective role in controlling bacterial overgrowth in the intestine (Inagaki et al., 2006).”