Fibroblast growth factors.

By I. Mason. Current Biology, 2018

2,069 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aff86782d3e598e46d00d368499baf7e0189df12

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Citations in the corpus

Urothelial tumorigenesis: a tale of divergent pathways (2005, background): “FGFR3 is one of four members (FGFR1–4) of a structurally conserved tyrosine kinase receptor family that are crucial for embryonic development, cell growth, differentiation, proliferation and angiogenesis (reviewed in Ref”
Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans (2008, background): “he fibroblast growth factor (FGF) family is composed of 22 members with a wide range of biological functions, including cell growth, development, angiogenesis and wound healing (1-5).”
FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. (2002, background): “FGFs comprise a family of 22 genes encoding structurally related proteins (Ornitz and Itoh 2001).”
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth (2003, background): “Four FGFR tyrosine kinases bind with varying affinity and specificity to a family of 22 FGF ligands (Ornitz and Itoh, 2001).”
Functions of heparan sulfate proteoglycans in cell signaling during development (2004, background): “FGFs are among the best-studied HSPG-binding proteins (Ornitz, 2000), and play many important roles in regulating cell proliferation, migration and differentiation during development (Coumoul and Deng, 2003; Ornitz and Itoh, 2001).”
Reaching a genetic and molecular understanding of skeletal development. (2002, background): “…there are 22 FGF proteins (Ornitz The formal demonstration that Sox9 plays a critical role during chondrogenesis came from an elegant mouseand Itoh, 2001), and deletion of these genes may result in embryonic lethality before chondrogenesis is initiated. embryo chimera experiment (Bi et al.,…”
Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration (2010, background): “Many FGF genes have been identified in vertebrates, including ten FGFs in zebrafish (FGF2–4, 6, 8, 10, 17a, 17b, 18, 24), six in Xenopus (FGF2–4, 8–10), 13 in chickens (FGF1–4, 8–10, 12, 13, 16, 18–20), 22 in mice (FGF1–18, 20–23) and humans (FGF1–14, 16–23), whereas only three Drosophila FGF genes ”
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. (2003, background): “The FGFs bind the extracellular domain of their cognate cell surface receptor (FGFR) and induce receptor dimerization and tyrosine kinase phosphorylation, which, in turn, leads to the activation of a number of intracellular pathways (Goldfarb 2001; Ornitz and Itoh 2001).”
Fibroblasts in fibrosis: novel roles and mediators (2014, background): “Despite the fact that this family has since been found to act on multiple cell types, FGFs require heparin or heparan sulfate proteoglycan molecules to bind their surface receptors (Ornitz and Itoh, 2001).”
FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development (2007, background): “The latter contains the invariant residues characteristic of the FGF core domain as well as several conserved residues implicated in binding of FGFs to Heparin and heparin sulphate proteoglycan (HSPG) (Bellosta et al., 2001; Ornitz, 2000; Ornitz and Itoh, 2001) (see Fig.”
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (2003, background): “These gene families include tumor necrosis factors (Flavell 2002), growth factors (Hackel et al. 1999; Cross and Claesson-Welsh 2001; Ornitz and Itoh 2001; Danielsen and Maihle 2002), cytokines (Schooltink and Rose-John 2002), chemokines (Onuffer and Horuk 2002), interferons (Grandvaux et al.…”
Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23 (2010, background): “A major tissue-specific alternative splicing event in the second half of D3 of FGFR1-3 creates epithelial lineage-specific “b” (FGFR1b-FGFR3b) and mesenchymal lineage-specific “c” (FGFR1c-FGFR3c) isoforms with distinct ligand-binding specificities (71).”