A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.

By B. Goodwin, Stacey A. Jones, R. R. Price, M. Watson, D. D. Mckee, L. Moore, C. Galardi, Joan G. Wilson, M. Lewis, M. Roth and 3 more. Molecules and Cells, 2000

1,900 citations recorded by the source corpus.

Subfields: Oncology, Pharmacology, Surgery

View Paper: https://www.semanticscholar.org/paper/98241074cd3f61d0fb5a7c05e7ccbaa612d6d502

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Citations in the corpus

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. (2003, methodology): “…the molecular mechanisms by which bile acids suppress CYP7A1 expression, and it is now apparent that multiple, redundant pathways exist (Stravitz et al. 1995; Antes et al. 2000; Goodwin et al. 2000; Lu et al. 2000; Miyake et al. 2000; De Fabiani et al. 2001; Kerr et al. 2002; Wang et al. 2002).”
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “The interplay between FXR and SHP is able to inhibit HNF-4a activity and, thus, to inhibit the expression of the mentioned three key enzymes involved in bile acid synthesis (Stroup et al. 1997; Chiang et al. 2000; Goodwin et al. 2000; Zhang and Chiang 2001; Chen and Chiang 2003).”
Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “A complex regulatory sequence containing overlapping binding sites for the orphan NRs HNF4 and LRH-1, and the retinoic acid receptors, conveys a positive regulation of the Cyp7A1 gene upon HNF4 or LRH-1 binding.”
Farnesoid X receptor is essential for normal glucose homeostasis. (2006, methodology): “Feeding a 1% CA diet for 5 days increased SHP expression in WT mice and strongly decreased CYP7A1 expression, as expected (4, 11, 24).”
Nuclear receptors — a perspective from Drosophila (2005, background): “These cross-regulatory interactions among fly orphan receptors provide an interesting parallel to studies of regulatory specificity that are conferred by vertebrate nuclear-receptor interaction”
Gut microbiota functions: metabolism of nutrients and other food components (2017, background): “Through binding to these receptors, bile acids can regulate genes critical to their synthesis, conjugation, transport, and detoxification [75–77] as well as lipid [78, 79] and glucose metabolism [80, 81] and energy homeostasis [82].”
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR (2012, background): “In addition to inducing gene expression directly, FXR mediates the repression of a number of genes indirectly through the regulation of SH”