Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

By Q. Tang, J. Y. Adams, A. J. Tooley, Mingying Bi, B. Fife, P. Serra, P. Santamaria, R. Locksley, M. Krummel, J. Bluestone. Nature Immunology, 2006

880 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/c2976746d4c28e238186f39006f170ebe39f243f

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Citations in the corpus

Regulatory T cells: how do they suppress immune responses? (2009, result): “These possible suppressive mechanisms are in accord with in vivo finding utilizing intra-vital two-photon microscopy, which demonstrate that Tregs apparently inhibit stable contacts between antigen-activated T cells and DCs ( 63 , 64).”
Regulatory T cells and immune tolerance. (2008, result): “Consistent with this model, intravital imaging of Tregs and responder T cells in a lymph node by two-photon microscopy suggests that activated Tregs hamper stable contacts between responder T cells and antigen-presenting dendritic cells (Tang et al., 2006; Tadokoro et al., 2006).”
The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “atic lymph nodes (110, 111), thus limiting T-cell priming”
How regulatory T cells work (2008, background): “These interactions were proposed to function in attenuating effector T-cell activation by DC”
Regulatory T cells exert checks and balances on self tolerance and autoimmunity (2010, result): “Although further investigation is needed, these findings are in accord with the in vivo finding using intravital two-photon microscopy demonstrating that T reg cells apparently inhibit stable contacts between antigen-activated T cells and DC”
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. (2008, methodology): “Our previous work showed that Treg cells effectively prevent the interaction of Teff cells with dendritic cells (DCs) ( Tang et al., 2006 ).”
TGF-beta: a master of all T cell trades. (2008, neutral): “cell differentiation (Tang et al., 2006).”
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells (2007, result): “1 + cells in the MLNs and colon showed normal proliferation, in line with published in vivo observation”
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. (2007, neutral): “Following Treg transfer, we observed DCs in close contact with T-regs in the colon as described in NOD pancreatic LN(Tang et al., 2006).”
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells (2006, background): “Because IL-2 is an “early cytokine” produced rapidly by activated T cells in the draining lymph nodes, IL-2 may be a critical signal for awakening the T reg cell response that can eff ectively suppress T cell expansion in these lymphoid tissues (45).”
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice (2007, background): “In addition, imaging studies have suggested that T reg cells diminish the ability of DCs to form stable contacts with self-reactive T cells and thereby diminish their activatio”
Mechanisms of foxp3+ T regulatory cell-mediated suppression. (2009, background): “Two studies have used two-photon laser scanning microscopy to examine potential interactions between antigen-specific Treg cells and DCs in lymph nodes (Tang et al., 2006; Tadokoro et al., 2006).”
Phenotypic and functional specialization of FOXP3+ regulatory T cells (2011, background): “Indeed, time-lapse imaging studies have revealed that T Reg cells form long-lasting, stable contacts with DCs, and this has led to the hypothesis that a primary mode of T Reg cell-mediated suppression within lymphoid tissues may be through inhibition of DC activation and/or functio”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “Finally, longlasting Treg cell interactions with dendritic cells were convincingly documented by recent studies employing intravital microscopy (213, 214).”
Regulatory T cells and infection: a dangerous necessity (2007, background): “Recently performed in vivo imaging indicates that natural T Reg cells form long-lasting interactions with dendritic cells (DCs) soon after they enter the lymph nodes, and this impairs the ability of DCs to subsequently activate effector T cells, indicating that, in vivo , natural T Reg cells ma”
A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells (2007, background): “Growing evidence indicates that T reg cells directly interact with DCs, but not effector T cells, to mediate their suppressor functio”