Regulatory T cells and immune tolerance.

By Shimon Sakaguchi, Tomoyuki Yamaguchi, T. Nomura, M. Ono. Cell, 2008

5,291 citations recorded by the source corpus.

Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/901ded0578c3b36419a85752e3eb354cc24fd506

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In Immunology

Citations in the corpus

New insights into the regulation of T cells by γc family cytokines (2009, neutral): “In addition, it contributes to the development of regulatory T (T Reg ) cells and therefore peripheral T cell toleranc”
Fat Treg cells: a liaison between the immune and metabolic systems (2009, background): “T reg cells, a small subset of T lymphocytes, normally constituting only 5–20% of the CD4 + compartment, are thought to be one of the body's most crucial defenses against inappropriate immune responses, operating in contexts of autoimmunity, allergy, inflammation, infection and tumorigenesi”
T-bet controls regulatory T cell homeostasis and function during type-1 inflammation (2009, background): “org/molecule/query?afcsid=A002750">A002750 ) is required for the development of CD4 + regulatory T cells (T reg cells”
Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors (2016, neutral): “In many cases, different sets of cytokines have the opposite effect of suppressing the immune response (Sakaguchi et al., 2008).”
The Microbiome in Infectious Disease and Inflammation (2012, neutral): “Treg cells regulate immune responses through multiple mechanisms, including the expression of immune-suppressive molecules such as CTLA-4, IL-10, TGF-β, and IL-35, but also the depletion of ATP and IL-2 (28, 208).”
Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria (2017, background): “LAG3, as well as other IRs, are also highly expressed on regulatory T cells (Tregs) (11–14), a critical suppressive subpopulation of T cells that prevents autoimmunity but limits antitumor immunity (15, 16).”
Acute pharmacological degradation of Helios destabilizes regulatory T cells (2021, neutral): “Regulatory T cells (Tregs) are a specialized subset of CD4+ T cells that maintain normal immune tolerance and homeostasis but also repress the anti-tumor immune response 1,2 .”
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2 (2012, background): “It is widely recognized that stronger TCR signals are important for T reg cell development (Sakaguchi et al., 2008), in contrast to the PD-1–mediated attenuation of TCR signals.”
Development and maintenance of regulatory T cells. (2013, background): “…CD25+CD4+ regulatory T (Treg) cells, which constitutively express the transcription factor Foxp3, are indispensable for the maintenance of immune self-tolerance and homeostasis by suppressing aberrant or excessive immune responses harmful to the host (Rudensky, 2011; Sakaguchi et al., 2008).”
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects (2020, background): “currently considered to be a classical combined marker of Tregs [16, 17].”