Regulatory T cells exert checks and balances on self tolerance and autoimmunity

By K. Wing, Shimon Sakaguchi. Nature Immunology, 2010

1,127 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/915813ef8809cab5d51dd3f04674451e349a40ad

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Citations in the corpus

Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells. (2016, background): “CD4+ regulatory T cells (CD4Tregs), defined by expression of CD25 and FoxP3, play an indispensable role in the maintenance of self-tolerance and immune homeostasis (7, 8).”
Organisms or biological individuals? Combining physiological and evolutionary individuality (2016, background): “Yet self constituents can trigger immune responses in healthy conditions (Anderton and Wraith 2002; Wing and Sakaguchi 2010; Germain 2012; Wynn et al. 2013) (Sakaguchi 2000; Bouneaud et al. 2000; Stefanová et al. 2002; Savill et al. 2002; Taylor et al. 2004; Sakaguchi 2006; Zehn and Bevan 2006;…”
Tolerance and Exhaustion: Defining Mechanisms of T cell Dysfunction (2013, neutral): “However, central tolerance is incomplete, in part because not all peripheral self-antigens are adequately presented in the thymus; self-reactive T cells that escape negative selection must be inactivated in the periphery by a series of tolerizing mechanisms that can include deletion [11–13], suppres”
CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation (2013, background): “Spreading of tolerance is a mechanism by which T cells keep the immune system in check (32).”
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses (2011, background): “and is important for the generation of regulatory T cells that act to suppress activation of the immune system and thereby maintain immune system homeostasis and tolerance to self antigen”