CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

By P. Pandiyan, Lixin Zheng, S. Ishihara, J. Reed, M. Lenardo. Nature Immunology, 2007

1,338 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fa8fc400f7c7167844d2603028159e2297779cec

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Citations in the corpus

Regulatory T cells: how do they suppress immune responses? (2009, background): “In addition, cytokine absorption by Tregs induces cytokine deprivation-mediated apoptosis in responder T cells ( 36 ).”
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. (2008, background): “693 IL-7, and IL-15 can help to sustain Treg cell survival in vitro through the provision of anti-apoptosis signals ( Pandiyan et al., 2007 ).”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “While indispensable in Treg cell homeostasis (87, 197), high-level IL-2R expression on Treg cells could deprive effector T cells of IL-2 and inhibit their proliferation (198).”
Regulatory T Cells and Human Disease. (2020, background): “CD8+ T cells, in particular self-reactive CD8+ T cells, can be driven to anergy and apoptosis in vitro by deprivation of IL-2 and costimulatory signal (see below) (59, 61).”
Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “This preferential consumption of IL-2 has been suggested to represent another key mechanism by which Treg cells mediate suppression and immune tolerance (Pandiyan et al., 2007).”
Mechanisms of foxp3+ T regulatory cell-mediated suppression. (2009, background): “One study (Pandiyan et al., 2007) has raised the possibility that Treg cells may compete with Foxp3 T cells for IL-2, consume it, and inhibit the proliferation of Foxp3 T cells, resulting in a form of apoptosis dependent on the proapoptotic factor Bim.”
How regulatory T cells work (2008, result): “, a recent study has re-ignited interest in this question by suggesting that T Reg cells induce cytokine (specifically IL-2)-deprivation-mediated apoptosi”
T Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis (2012, background): “colleagues (28) suggested that Tregs can essentially "starve" effector cells by depleting local resources of IL-2, leading to effector cell apoptosis.”
Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, positive): “Moreover, different populations of responding cells can potentially compete for IL-2, and Treg cells expressing high affinity IL-2Rs can efficiently compete for limited amount IL-2 with effector cells that express intermediate affinity IL-2Rs (Busse et al., 2010; Pandiyan et al., 2007).”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “A study by Lenardo's group proposed that Tregs induce IL-2 deprivation-mediated apoptosis in mouse Tcons, which was dependent on close proximity between the cells (Pandiyan et al., 2007).”
The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “reported that consumption of IL-2 by Tregs can result in cytokine deprivation-induced apoptosis of effector T cells (96, 97).”