Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system.
By W. Garrett, Graham M Lord, Shivesh Punit, G. Lugo-Villarino, S. Mazmanian, S. Ito, J. Glickman, Laurie H. Glimcher. Cell, 2007
964 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/e92eaf53a56a21f890d76f0b4b95ed2fb970e5c8
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Citations in the corpus
- Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease (2012, background): “In fact, dysbiotic microbiota can induce murine colitis [114], and is observed in IBD patients by the reduction in microbial diversity [115,116], the enrichment of bacteria from the family Enterobacteriaceae [117–119] and the depletion in bacteria”
- Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling (2015, background): “Remarkably, disease-promoting dysbiotic microbiota in multiple mouse models harbors dominance, upon fecal transfer, over a previously stable wild-type (WT) microbiota, leading to transferable disease susceptibility (Couturier-Maillard et al., 2013; Elinav et al., 2011; Garrett et al., 2007; Henao-Me”
- The immune system and the gut microbiota: friends or foes? (2010, result): “Intestinal inflammation spontaneously progresses to colonic dysplasia and rectal adenocarcinoma; therefore, disease progression in this model is similar to that seen in human IB”
- Metagenomic biomarker discovery and explanation (2011, background): “Its loss in the absence of an adaptive immune system results in a highly penetrant and aggressive form of ulcerative colitis [65] that is specifically dependent on and transmissible through the gut flora.”
- Defining dysbiosis and its influence on host immunity and disease (2014, background): “Klebsiella pneumonia and Proteus mirabilis, both members of the Enterobacteriaceae family, also expanded to induce colitis within T-bet−/− X Rag2−/− mice (Garrett et al., 2007).”