Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

By J. Kim, J. P. Rasmussen, Alexander Y. Rudensky. Nature Immunology, 2007

1,903 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/aa04f17959a8f40e96999cc68c9c878ea0ce9e2b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation (2011, positive): “Likewise, ablation of Treg cells in adult healthy mice leads to augmented generation of Th1, Th2, and Th17 cells and death within 2 weeks fromhighly aggressive inflammatory lesions in a variety of organs (Kim et al., 2007).”
Fat Treg cells: a liaison between the immune and metabolic systems (2009, result): “, unpublished data), similar to what has been described by another group with their independently derived lin”
A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells (2007, background): “T regulatory cells (T reg cells) positive for expression of the transcription factor Foxp3 have a dominant function in active immune suppression and the maintenance of immune homeostasi”
Regulatory T cells and immune tolerance. (2008, background): “Recent analyses reveal that Foxp3-expressing T cells appear shortly after birth and show that the development of autoimmune/inflammatory disease follows their depletion (Kim et al., 2007; Lahl et al., 2007).”
Autosomal-dominant immune dysregulation syndrome in humans with CTLA4 mutations (2014, positive): “The mammalian immune system contains self-reactive T cells, which are controlled by FOXP3 + T reg cells 7,8 .”
The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “Evidence from numerous groups has shown that either depletion of CD25CD4 Tregs or ablation of Foxp3 Tregs results in the development of autoimmune disease (61, 66, 75).”
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 (2007, background): “A similar precipitously lethal disease is also found in neonatal and adult mice subjected to diphtheria toxin–induced ablation of the entire T reg cell subset genetically tagged with the diphtheria toxin recepto”
A two-step process for thymic regulatory T cell development. (2008, background): “Moreover, acute depletion of Foxp3-expressing cells turns a normal resting immune system into one that is hyperactive and uncontrolled, resulting in the death of an adult animal within a mere 10 days (Kim et al., 2007; Lahl et al., 2007).”
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma (2013, background): “Widespread depletion of T reg cells can induce multiple autoimmune pathologies (Fontenot et al., 2003; Kim et al., 2007).”
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells (2012, background): “As a consequence, experimental or clinical manipulation of the entire Foxp3+ T reg compartment could have catastrophic consequences (Kim et al., 2007).”
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells through targeting SOCS1 (2009, background): “Mice Mirn155 / (Thai et al., 2007), Foxp3DTR (Kim et al., 2007), SOCS1 Tg (Hanada et al., 2003), and SOCS1 cKO (Tanaka et al., 2008) mice were described elsewhere.”
A Special Population of Regulatory T Cells Potentiates Muscle Repair (2013, positive): “) starting from the time of im Ctx injection and were analyzed 1 week later, a time chosen to avoid the multiorgan autoimmunity provoked by long-term ablation of Treg cells (Kim et al., 2007).”
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans (2013, background): “In addition, it has been demonstrated in animal models that depletion of Treg cells as a whole can trigger autoimmunity (1, 16, 17).”