A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells

By A. Awasthi, Y. Carrier, J. Peron, E. Bettelli, M. Kamanaka, R. Flavell, V. Kuchroo, M. Oukka, Howard L. Weiner. Nature Immunology, 2007

870 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/ca6a67651346bcae8735c18a0a4555aca3062270

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In Immunology

Citations in the corpus

Oral tolerance (2011, background): “These induced Tregs may also condition DCs to secrete IL-27 and in turn induce IL-10-secreting Tr1 cells (64).”
TGF-β Activation and Function in Immunity (2013, background): “McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, et al. TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology.”
The composition and signaling of the IL-35 receptor are unconventional (2012, background): “and blocking T H 17 differentiation and the TGF-β-driven formation of induced T reg cells and IL-10 productio”
Normalization of Obesity-Associated Insulin Resistance through Immunotherapy: CD4+ T Cells Control Glucose Homeostasis (2009, background): “Regulatory T cells and inducible type 1 regulatory T cells produce IL-10, a major anti-inflammatory cytokine, as part of their effector functio”
Interleukin 4 inhibits TGF-β-induced-Foxp3+T cells and generates, in combination with TGF-β, Foxp3− effector T cells that produce interleukins 9 and 10 (2008, background): “Several papers have demonstrated that IL-27 together with TGF-β induces the differentiation of Tr1 cell”
CD4+T Cells: Differentiation and Functions (2012, neutral): “driving the Tr1 cells differentiation [97, 98].”
Regulation of the immune response by the aryl hydrocarbon receptor (2018, background): “IL-27 promotes Tr1 cell differentiation (Awasthi et al., 2007; Fitzgerald et al., 2007; Stumhofer et al., 2006), while IL-21 acts in an autocrine manner to stabilize these cells (Pot et al., 2009; Spolski et al., 2009).”