Phenotypic and functional specialization of FOXP3+ regulatory T cells

By D. Campbell, M. Koch. Nature reviews. Immunology, 2011

815 citations recorded by the source corpus.

Forkhead box P3 (FOXP3)+ regulatory T (TReg) cells prevent autoimmune disease, maintain immune homeostasis and modulate immune responses during infection. To accomplish these tasks, TReg cell activity is precisely controlled, and this requires TReg cells to alter their migratory, functional and homeostatic properties in response to specific cues in the immune environment. We review progress in understanding the diversity of TReg cells, TReg cell function in different anatomical and inflammatory settings, and the influence of the immune environment on TReg cell activity. We also consider how these factors affect immune-mediated disease in the contexts of infection, autoimmunity, cancer and transplantation.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/eef99f1d11a48d06becef2bd3b91b0ed1ae2875e

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In Immunology

Citations in the corpus

IL-2 Family Cytokines: New Insights into the Complex Roles of IL-2 as a Broad Regulator of T helper Cell Differentiation (2011, background): “Nevertheless, the way in which IL-2 affects Treg function remains incompletely understood [58].”
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020, result): “Macrophages and/or MDSCs highly expressed several potential mediators of Treg recruitment, including CXCL9/10/11 (to CXCR3), CCL4 (toCCR4/8), andCCL20 (toCXCR3 andCCR6), consistent with prior studies (Campbell and Koch, 2011; Liu et al., 2011; Redjimi et al., 2012).”
Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells (2016, background): “Treg cells adapt their transcriptional program to the various cytokines to which they are exposed in the inflammatory milieu (Campbell and Koch, 2011).”
T Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis (2012, background): “It is possible that numerous additional chemokines regulate Treg recruitment in cancer [see Campbell and Koch (36) for a list of potentially important chemokine”
Development and maintenance of regulatory T cells. (2013, background): “Recent work has demonstrated that Treg cells are able to adapt to environmental signals and further differentiate by expressing transcription factors normally associated with Th cell subsets (Campbell and Koch, 2011).”