TGF-beta: a master of all T cell trades.

By Ming O. Li, R. Flavell. Cell, 2008

902 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b646d61ce8bc99f5cbcc780e666fa289b553de85

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Citations in the corpus

TGF-beta and fibrosis in different organs - molecular pathway imprints. (2009, neutral): “However, TGF-β is clearly a bi- (or multi-) functional molecule with strong effects on the immune system [4,5].”
Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, neutral): “Thus, in the periphery, TGF-b is necessary for the survival of naı̈ve T cells and it also maintains peripheral tolerance by inhibiting the proliferation and differentiation of self-reactive CD4 and CD8 T cells [2,3].”
Tissue-Resident Memory T Cells (2014, background): “Although it is uncertain whether this is related to a lack of TGF-bR expression, responsiveness to TGF-b is clearly dependent on T cell differentiation state (Li and Flavell, 2008).”
Oral tolerance (2011, neutral): “Furthermore, with the identification of forkhead box protein 3 (Foxp3) as a key transcription factor for thymus-derived natural regulatory T cells, ‘suppressor cells’ are now called ‘Tregs’, and TGF-b is now recognized as a key cytokine in the induction of Foxp3 Tregs and other T-cell subsets (12).”
The Balance of Th17 versus Treg Cells in Autoimmunity (2018, background): “However, TGF-β inhibits differentiation of Th1 and Th2 cells, and IL-2 inhibits that of Th17 cells [66,67].”
Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling (2011, positive): “…through activation of Smad2 and Smad3, plays an essential role in normal development and tissue homeostasis as well as in human diseases from cancer to autoimmunity to cirrhosis (Friedman, 2008; Li and Flavell, 2008; Massagué et al., 2005; Padua and Massagué, 2009; Wandzioch and Zaret, 2009).”
The polarization of immune cells in the tumour environment by TGFβ (2010, background): “TGFβ inhibits T-bet and GATA-binding protein 3 (GATA3) expression (which determine CTL, T H 1 and T H 2 cell differentiation), whereas it promotes forkhead box P3 ( FOXP3 ) and retinoic acid receptor-related orphan receptor-γt ( RORγt ) expression (which determine T Reg and T H 17 cell differentiat”