How regulatory T cells work

By D. Vignali, L. Collison, C. Workman. Nature reviews. Immunology, 2008

3,336 citations recorded by the source corpus.

Regulatory T (TReg) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilizing immunity and limiting antitumour immunity. Given that TReg cells can have both beneficial and deleterious effects, there is considerable interest in determining their mechanisms of action. In this Review, we describe the basic mechanisms used by TReg cells to mediate suppression and discuss whether one or many of these mechanisms are likely to be crucial for TReg-cell function. In addition, we propose the hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate TReg-cell function.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/91921523f0974262fa06a75928b3cbd059ed4532

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Citations in the corpus

Plasticity of CD4+ T cell lineage differentiation. (2009, background): “Treg cells have essential roles in maintenance of immune homeostasis, regulating these effector T cell responses and thus preventing their potentially pathogenic effects through a variety of mechanisms (Vignali et al., 2008; Shevach, 2009, this issue of Immunity).”
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke (2009, background): “Although we cannot rule out that other T reg cells mediators, including TGF-β and cytotoxic T lymphocyte antigen-4, or their direct cellular interactions contribute to T reg cell–induced protection, we concentrated on IL-10 as a universal signaling mechanism used by T reg cell”
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation (2011, neutral): “Although Treg cell-mediated suppression is not fully understood in mechanistic terms, various studies indicate that Treg cells utilizemultiplemeans to accomplish suppressionof different inflammatory responses (Shevach, 2009; Vignali et al., 2008).”
Phenotypic and functional specialization of FOXP3+ regulatory T cells (2011, background): “However, numerous other mechanisms have been implicated in T Reg cell function in both lymphoid and non-lymphoid tissues in various experimental setting”
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses (2018, positive): “Given the fact that our immune system is composed of many different T cell subtypes with distinct effector functions (Golubovskaya and Wu, 2016; Vignali et al., 2008; Vivier et al., 2008), regulating the activity of T cell subtypes independently may be an attractive strategy for optimizing the effic”
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses (2011, background): “Given that no single mechanism accounts for T Reg cell suppressive functio”
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells (2009, background): “Foxp3 is a transcription factor only expressed in the T reg cell lineage (Fontenot et al., 2003; Hori et al., 2003; Vignali et al., 2008).”
The composition and signaling of the IL-35 receptor are unconventional (2012, background): “Regulatory T cells (T reg cells) are necessary for immune homeostasis and to prevent autoimmunity, yet they also limit antitumor immunit”