A vesicular transport pathway shuttles cargo from mitochondria to lysosomes.

By Vincent Soubannier, Gian-Luca McLelland, R. Zunino, Emélie Braschi, P. Rippstein, Edward A. Fon, H. McBride. Current Biology, 2012

720 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/fd306fef66c9aa5050ef43cf95d220b64db60639

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Citations in the corpus

To be or not to be? How selective autophagy and cell death govern cell fate. (2014, positive): “That said, there is evidence that, even in the absence of ATG5 and ATG7, some selective mitophagy continues via unknown mechanisms, perhaps via vesicular trafficking between mitochondria and lysosomes (Soubannier et al., 2012).”
The pathways of mitophagy for quality control and clearance of mitochondria (2012, background): “In addition to proteolytic and proteosomal degradation, recent evidence points to a lysosomal pathway in which vesicles bud from mitochondrial tubules, sequester selected mitochondrial cargos, and then deliver those mitochondrial components to the lysosome for degradation.(7) This pathway is active ”
Measuring in vivo mitophagy (2015, background): “One recently described form of mitophagy involves a process in which parts of mitochondria can bud off and transit tomultivesicular bodies, which in turn ultimately fuse with the lysosome (Lemasters, 2014; Soubannier et al., 2012; Sugiura et al., 2014).”
Mitochondria-lysosome contacts regulate mitochondrial fission via Rab7 GTP hydrolysis (2018, neutral): “4d–f), distinct from previously described Tom20-positive MDVs 23 .”
Mitochondria: In Sickness and in Health (2012, background): “III, stimulates the biogenesis of vesicles that carry mitochondrial cargo that fuse with lysosomes, suggesting that this pathway functions in quality control (Soubannier et al., 2012).”
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control (2014, background): “…oxidase, which induces ROS formation external to mitochondria, for 2 h— a treatment that triggers the robust formation of TOM20-positive/ matrix-negative vesicles (Soubannier et al, 2012a)—we again did not observe the recruitment GFP-parkin to these MDVs (Supplementary Fig S2B, open arrowheads).”
A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles (2014, methodology): “MDVs are formed in the absence of the mitochondrial dynamin GTPase Drp1, indicating additional mechanisms are also required for the final scission event (Neuspiel et al, 2008; Soubannier et al, 2012a; McLelland et al, 2014).”