The pathways of mitophagy for quality control and clearance of mitochondria

By Ghazaleh Ashrafi, Thomas Schwarz. Cell Death and Differentiation, 2012

1,775 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dfc0ab4d6f4ee6ecdd626f47ea59b4c6dcd92aee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. T. Lamark
2. T. Johansen
3. Å. Birgisdottir
4. V. Deretic
5. I. Slaninová

In Molecular Biology

1. T. Johansen
2. T. Lamark
3. Å. Birgisdottir
4. V. Deretic

Citations in the corpus

• The LIR motif – crucial for selective autophagy (2013, background): “Both yeast and mammalian cells can selectively eliminate damaged or superfluous mitochondria by mitophagy (reviewed by Ashrafi and Schwarz, 2013).”
• Transcellular degradation of axonal mitochondria (2014, background): “Damaged mitochondria are removed by mitophagy, a subtype of autophagy that involves the enwrapping of mitochondria in autophagosomes that subsequently fuse with lysosomes to become autophagolysosomes (2).”
• Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation (2023, background): “Among these mechanisms, the PTEN induced putative kinase 1 (PINK1)/Parkin pathway is currently the most widely studied, which is involved in the elimination of damaged mitochondria in mammals [12].”
• The mitophagy pathway and its implications in human diseases (2023, background): “The homeostasis of mitochondria is sustained by an equilibrium of removal and bioproduction, which can be disrupted by uncontrolled mitophagy.(2,4) This brings about mitochondrial suboptimal state, leading to diseases of the nervous system, cardiovascular (or heart), lung, liver, kidney, skeletal mu”