A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles

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Mitochondria-lysosome contacts regulate mitochondrial fission via Rab7 GTP hydrolysis (2018, neutral): “Moreover, mitochondria in contact with lysosomes were significantly larger in size (>500 nm) than MDVs (~100 nm) 7 and contained mitochondrial matrix proteins (Fig.”
Mitochondria in the regulation of innate and adaptive immunity (2015, positive): “There is precedent that mitochondria can transport proteins and lipids through small vesicular carriers (Sugiura et al., 2014).”
Measuring in vivo mitophagy (2015, background): “One recently described form of mitophagy involves a process in which parts of mitochondria can bud off and transit tomultivesicular bodies, which in turn ultimately fuse with the lysosome (Lemasters, 2014; Soubannier et al., 2012; Sugiura et al., 2014).”
Compromised MAPK signaling in human diseases: an update (2015, background): “PINK1 thus appears to be essential for mitochondrial homeostasis including mitochondrial quality control (Sugiura et al. 2014).”
Metabolic regulation of mitochondrial dynamics (2016, background): “Pink1 and Parkin have also been implicated in another mitochondrial quality control pathway, distinct from autophagy, in which vesicles bud off from mitochondria and are trafficked to the late endosome and lysosome (McLelland et al., 2014; Sugiura et al., 2014).”