Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
By Gian-Luca McLelland, Vincent Soubannier, C. X. Chen, H. McBride, Edward A. Fon. EMBO Journal, 2014
722 citations recorded by the source corpus.
Subfields: Epidemiology, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/a243b0f865621caa1aa824676996bd15ac19a65b
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Citations in the corpus
- A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles (2014, background): “The second important finding was that the generation of MDVs destined for lysosomes required the protein kinase PINK1 and the cytosolic ubiquitin E3 ligase Parkin (McLelland et al, 2014).”
- Mitochondrial dynamics and mitochondrial quality control (2014, background): “In addition, vesicles bud off of damaged mitochondria and are degraded in the lysosome independent of the canonical autophagy pathway [88].”
- Measuring in vivo mitophagy (2015, background): “, ATG5 and LC3 independent) while still requiring PINK1 and Parkin function (McLelland et al., 2014).”
- The Roles of PINK1, Parkin and Mitochondrial Fidelity in Parkinson's Disease (2015, background): “PINK1 and Parkin can remove small pieces of vesicles from mitochondria (McLelland et al., 2014; Yang and Yang, 2013).”
- Deciphering the Molecular Signals of PINK1/Parkin Mitophagy. (2016, background): “Interestingly, both PINK1 and Parkin have been shown to also function in a quality control pathway parallel to mitophagy by facilitating piecemeal degradation of mitochondria via the formation of mitochondria-derived vesicles (MDVs) [79].”
- Metabolic regulation of mitochondrial dynamics (2016, background): “Pink1 and Parkin have also been implicated in another mitochondrial quality control pathway, distinct from autophagy, in which vesicles bud off from mitochondria and are trafficked to the late endosome and lysosome (McLelland et al., 2014; Sugiura et al., 2014).”
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “PINK1 and PARK2 also participate in an ATG gene-independent pathway for lysosomal degradation of small mitochondria-derived vesicles.(790) Furthermore, the PINK1-PARK2 mitophagy pathway is also transcriptionally upregulated in response to starvation-triggered generalized autophagy, and is intertwine”