Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

By E. Ziviani, R. Tao, Alexander J. Whitworth. Proceedings of the National Academy of Sciences of the United States of America, 2010

754 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/c35ce26955a0952027e404cd9011debe37316889

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Citations in the corpus

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy (2011, background): “In Drosophila, mitofusin (dmfn) is ubiquitinated and downregulated by Parkin (11,21).”
Mitochondria: In Sickness and in Health (2012, background): “Recent studies specifically connect PINK1/Parkin-mediated autophagy with mitochondrial dynamics and motility, providing evidence that Parkin ubiquitinates MFN1, MFN2, and Miro in cultured cells, leading to their degradation and consequently altering mitochondrial behavior (Chan et al., 2011; Gegg et”
The Roles of PINK1, Parkin and Mitochondrial Fidelity in Parkinson's Disease (2015, background): “Mfn1 and Mfn2 are ubiquitinated and degraded by the proteasome in a Parkin-dependent manner (Gegg et al., 2010; Poole et al., 2010; Rakovic et al., 2011; Tanaka et al., 2010; Ziviani et al., 2010).”
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin (2010, background): “, 2010), and Marf (Ziviani et al., 2010) was found to be ubiquitinated dependent on Parkin and PINK1 expression.”
Mitochondrial fusion and fission in cell life and death (2010, background): “melanogaster mitofusin was identified as a target for ubiquitylation by Parki”
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences (2012, positive): “…of parkin-induced mitophagy, it has been observed that parkin mediates ubiquitination and proteasomal degradation of Mfn1 and Mfn2 in response to mitochondrial uncoupling (Poole et al , 2008; Gegg et al , 2010; Tanaka et al , 2010; Ziviani et al , 2010; Chan et al , 2011; Glauser et al , 2011).”
Mechanisms of mitophagy (2011, background): “In mitochondria, four substrates of parkin have been identified: the mitofusin mitochondrial assembly regulatory factor (MARF) in flie”
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization (2013, background): “iron-sulphur shuttling (CISD1), (5) protein translocation (TOMM70) or (6) proteasome assembly or activity (PSMC subunits) (see Supplementary Text)(25,27).”
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control (2014, background): “…triggers whole-mitochondrial engulfment by autophagosomes and subsequent degradation through the autophagosome-lysosome pathway (a process known as mitophagy; Narendra et al, 2008; Geisler et al, 2010; Poole et al, 2010; Tanaka et al, 2010; Ziviani et al, 2010; Wang et al, 2011; Sun et al, 2012).”
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “However, this proteasome-dependent degradation of Mfns requires the overexpression of the E3-ubiquitin-ligase Parkin (Tanaka et al., 2010; Ziviani et al., 2010; Chan et al., 2011).”
The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “In mammalian cells, additional E3 ligases as MULAN and MARCH5 modify mitochondrial dynamics, and in the case of the latter, ubiquitinates Mfn1 (54, 84).”