Mitochondrial fusion and fission in cell life and death

By B. Westermann. Nature reviews. Molecular cell biology, 2010

1,947 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/057a29972a9896a07e3b0113a4294ea5c483e0ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. D. C. Chan
2. Hsiuchen Chen
3. R. Youle
4. Zhiyin Song
5. A. M. van der Bliek
6. S. Kawajiri
7. Qinfang Shen
8. O. Loson

In Molecular Biology

1. D. C. Chan
2. R. Youle
3. Hsiuchen Chen
4. A. M. van der Bliek
5. W. Ding
6. Zhiyin Song
7. J. Martinou
8. S. Kawajiri

Citations in the corpus

• Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission (2013, background): “The opposing processes of fusion and fission (division) regulate mitochondrial morphology and function (Westermann, 2010; Chan, 2012; Youle and van der Bliek, 2012).”
• Molecular machines governing exocytosis of synaptic vesicles (2012, background): “This helps to explain why unrelated classes of fusion proteins evolved in parallel to the SNAREs, such as those fusing cells (95), viruses (96), mitochondria (97) or the endoplasmic reticulum (98).”
• BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells (2013, background): “These included the SLC25A42 and SLC25A38 mitochondrial carriers that transport metabolites and amino acids across the mitochondrial membrane, and the gene FIS1, which is critical for mitochondrial dynamics and fission (Figure 3A) (Westermann, 2010).”
• The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, background): “Instead, mitochondrial health and function rely on a dynamic process of mitochondrial fission and fusion followed by removal of damaged mitochondria (Westermann, 2010).”
• Mitochondria in Apoptosis: Bcl-2 family Members and Mitochondrial Dynamics (2011, background): “The core components of the fusion and fission machineries have been identified as the dynamin-related proteins Drp1, mitofusins (Mfn) 1 and 2, and Opa1 (Box 1) (reviewed in Westermann, 2010).”
• Mechanisms of mitochondrial fission and fusion. (2013, background): “are caused by mutations in fission and fusion proteins and the discovery of numerous connections with apoptosis and mitophagy (Westermann 2010; Chan 2012; Nunnari and Suomalainen 2012; Youle and van der Bliek 2012).”
• Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth (2015, background): “…of mean tumor volume (E) or tumor lecular Cell 57, 537–551, February 5, 2015 ª2015 Elsevier Inc. 539 A B D C E F G H I J (legend on next page) 540 Molecular Cell 57, 537–551, February 5, 2015 ª2015 Elsevier Inc. assembly into a ring structure, and the constriction of that ring (Westermann, 2010).”
• Mitochondrial dynamics and mitochondrial quality control (2014, background): “Mitochondrial fission and fusion and motility in mitophagy Mitochondria are dynamic organelles that continuously undergo fission and fusion, which are necessary for cell survival and adaptation to changing conditions needed for cell growth, division, and distribution of mitochondria during…”
• Pathophysiology of Type 2 Diabetes Mellitus (2020, background): “This process generates energy to maintain cell viability under unfavorable conditions and protects the cell during stress conditions [136,139].”
• Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “As discussed above, mitophagy plays an essential role in erythrocyte differentiation and maturation.”