The Interplay Between Mitochondrial Dynamics and Mitophagy

By G. Twig, Orian Shirihai. Antioxidants and Redox Signaling, 2011

746 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/90dc85363a38544e73adc480f2772a2b9ca60fc1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. Ghazaleh Ashrafi
2. Thomas Schwarz
3. R. Youle
4. W. Ding

In Epidemiology

1. W. Ding
2. Alicia M. Pickrell
3. Ghazaleh Ashrafi
4. Thomas Schwarz
5. Hong-Min Ni
6. Jessica A. Williams
7. Mohammad Hashemi
8. S. Ghavami

In Molecular Biology

1. M. Calkins
2. W. Ding
3. M. Mańczak
4. Alicia M. Pickrell
5. P. Reddy
6. Thomas Schwarz
7. Ghazaleh Ashrafi
8. R. Youle

Citations in the corpus

• Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. (2011, background): “The balance of this recycling, coupled with autophagy and biogenesis, is thought to maintain the overall health of mitochondria in the cell (59).”
• Mitochondrial dynamics and mitochondrial quality control (2014, background): “Moreover, knockdown of USP30 improves mitochondrial integrity in Parkinor Pink1-deficient flies and protects flies against paraquat toxicity in vivo by ameliorating defects in dopamine levels, motor function and organismal survival [61].”
• Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, positive): “Moreover, mitochondria form tubular structures by connecting to one another (mitochondrial fusion), during serum starvation, which also promptly induces autophagy (Twig and Shirihai, 2011).”
• The Roles of PINK1, Parkin and Mitochondrial Fidelity in Parkinson's Disease (2015, background): “However, as mitophagy has been linked to mitochondrial fission in yeast and mammals, perhaps the fission activity of PINK1 and Parkin in flies reflects mitochondrial division to segregate debris for autophagic elimination (Twig and Shirihai, 2011; Youle and van der Bliek, 2012).”
• The pathways of mitophagy for quality control and clearance of mitochondria (2012, background): “Similarly in mammals, genetic manipulations that cause excessive fusion, such as overexpression of Opa1 or dominant-negative Drp1, preclude autophagic degradation of mitochondria.(58) This protection from autophagy by hyperfusion occurs physiologically during certain types of starvation-induced auto”