Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

By M. Liesa, Orian Shirihai. Cell Metabolism, 2013

1,294 citations recorded by the source corpus.

Summary Mitochondrial fusion, fission and mitophagy form an essential axis of mitochondrial quality control. However, quality control may not be the only task carried out by mitochondrial dynamics. Recent studies link mitochondrial dynamics to the balance between energy demand and nutrient supply, suggesting changes in mitochondrial architecture as a mechanism for bioenergetic adaptation to metabolic demands. By favoring either connected or fragmented architectures, mitochondrial dynamics regulates bioenergetic efficiency and energy expenditure. Placing bioenergetic adaptation and quality control as competing tasks of mitochondrial dynamics may provide a new mechanism, linking excess nutrient environment to progressive mitochondrial dysfunction, common to age-related diseases.

Subfields: Clinical Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/771b781ba920a0a4d97ded9bf5e3e5d64cf63cec

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Citations in the corpus

Mitochondrial dysfunction: mechanisms and advances in therapy (2024, background): “296 Moreover, it was also demonstrated that the impact of impaired mitochondrial dynamics and quality control mechanisms, such as mitophagy, on insulin resistance and metabolic syndrome.”
Metabolic control of cell death (2014, background): “Conversely, mitochondria generally fragment in cells exposed to excess nutrients, a situation that presumably decreases the bioenergetic efficacy of the organelles and favors the removal of lipids and other potentially toxic molecules (16).”
The Mitochondrial Basis of Aging (2016, background): “Other processes not discussed here in depth include mitochondrial dynamics (Liesa and Shirihai, 2013; Pernas and Scorrano, 2015), as well as the biosynthetic properties of mitochondria.”
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth (2015, background): “Several of the biological processes affected by Ras signaling, including apoptosis, proliferation, metabolic reprogramming, and autophagy, are tightly linked to mitochondrial function, and each of these processes can be affected by alterations in the balance of mitochondrial fusion and fission, sugg”
Mitochondrial Cristae: Where Beauty Meets Functionality. (2016, background): “Signaling Pathways Modulating Cristae Morphology Mitochondria are able to change their morphology to match with the needs of the cells (reviewed in [76]).”