The machines that divide and fuse mitochondria

By J. Nunnari. Annual Review of Biochemistry, 2007

810 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/93830fbe895e0ce3fec1f8a7dcd097f53b3ab33d

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Citations in the corpus

Mechanics of membrane fusion (2008, background): “; and intracellular fusion reactions in exocytosis, protein trafficking, mitochondrial remodeling and resealing of plasma membrane”
Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death (2007, background): “However, opposite regulation of enzymes by neighbouring phosphorylation sites is well documented (Hudmon & Schulman, 2002).”
SLP‐2 is required for stress‐induced mitochondrial hyperfusion (2009, positive): “Mitochondrial ﬁssion due to impaired mitochondrial fusion is often accompanied by bioenergetics defects due to a loss of mitochondrial DNA (mtDNA) (Chan, 2006; Hoppins et al , 2007).”
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. (2008, background): “The processes of ﬁssion/fusion are controlled by GTPases, most of which were identiﬁed in genetic screens in yeast (for recent reviews see reference 4,5 ).”
Mitochondrial dynamics and apoptosis. (2008, background): “Dynamin-related protein 1 (Drp1), a large GTPase, mediates mitochondrial fission in mammalian cells (for reviews, see Okamoto and Shaw 2005; Hoppins et al. 2007).”
Mitochondria: In Sickness and in Health (2012, background): “Mitochondrial division and fusion aremediated by the action of large multidomain dynamin-related GTPases that function via self-assembly to remodel diverse membranes in cells (Hoppins et al., 2007).”
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells (2010, background): “mitochondrial networks, and this dynamic morphology is essential for normal mitochondrial and cellular functions (Karbowski and Youle, 2003; Okamoto and Shaw, 2005; Chan, 2006; McBride et al., 2006; Cerveny et al., 2007b; Hoppins et al., 2007; Benard and Karbowski, 2009).”
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice (2009, background): “…are highly dynamic organelles that continuously fuse and divide within cells (Karbowski and Youle, 2003; Osteryoung and Nunnari, 2003; Rube and van der Bliek, 2004; Okamoto and Shaw, 2005; Anesti and Scorrano, 2006; Chan, 2006; McBride et al., 2006; Cerveny et al., 2007a; Hoppins et al., 2007).”
Mitochondrial dynamics in mammalian health and disease. (2009, background): “strict the mitochondrial tubule by DRP1 oligomers, which surround it, thereby forming a spiral ring around the scission site (133, 143, 273, 327).”
Mitochondrial fusion and fission in cell life and death (2010, background): “Although most of the evolutionarily conserved core components of the mitochondrial fusion and fission machineries have been described in the past 15 years ( Table 1 ), more recent work revealed mechanistic insights into their molecular functio”
Mechanisms of mesenchymal stem/stromal cell function (2016, background): “, fusion, fission, tethering, and trafficking) [127, 128] may also promote or inhibit intercellular mitochondria transfer.”
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations (2010, positive): “INTRODUCTION Mitochondrial fusion and fission have emerged as important processes that govern mitochondrial function from yeast to mammals (Detmer and Chan, 2007a; Suen et al., 2008; Okamoto and Shaw, 2005; Hoppins et al., 2007).”
Mitochondrial Dysfunction in Parkinson's Disease (2011, background): “Several independent groups reported a role of PINK1 in mitochondrial integrity by regulating the mitochondrial fission machinery [95], which might have an impact on dopaminergic synapses and contribute to DA neuron degeneration [96–98].”