Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

By Hidenori Otera, Chunxin Wang, Megan M. Cleland, Kiyoko Setoguchi, S. Yokota, R. Youle, K. Mihara. Journal of Cell Biology, 2010

1,104 citations recorded by the source corpus.

Localization of the dynamin-related GTPase Drp1 to mitochondria relies on the mitochondrial fission factor Mff.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bf76f7cc9d6ea2b6ed515881d8361f07daa43444

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In Molecular Biology

1. D. C. Chan
2. Hsiuchen Chen
3. Prashant Mishra
4. Angelika S. Rambold
5. Xiongwei Zhu
6. Xinglong Wang
7. Jennifer Lippincott-Schwartz
8. A. M. van der Bliek

Citations in the corpus

• Metabolic regulation of mitochondrial dynamics (2016, background): “In cultured cells, Mff appears to be the primary receptor, because loss of Mff results in dramatic mitochondrial elongation (Gandre-Babbe and van der Bliek, 2008; Otera et al., 2010; Losón et al., 2013).”
• Cellular and molecular mechanisms of mitochondrial function (2012, background): “39,40 Much doubt has been cast on the proposed role of Fis1 as a bona fi de Drp1 receptor in mammalian systems.”
• MiD49 and MiD51, new components of the mitochondrial fission machinery (2011, background): “Other proteins have been implicated in mitochondrial fission, including endophilin BI (Karbowski et al, 2004), MARCH5 (Karbowski et al, 2007) and Mff (Gandre-Babbe & van der Bliek, 2008; Otera et al, 2010).”
• Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “…suggests that mitochondria fi ssion factor, a tail-anchored mitochondrial outer membrane protein that physically interacts with Drp1 but not Fis1, is an essential factor for Drp1-mediated mitochondria fi ssion in mammalian cells (Gandre -Babbe and van der Bliek 2008 ; Otera et al. , 2010 ).”
• Mechanisms of mitochondrial fission and fusion. (2013, background): “Subsequent work with a mistargeted protein in mammalian cells showed that Mff is sufficient to act as a Drp1 receptor (Otera et al. 2010).”
• Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease (2012, background): “Instead, mitochondrial fission factor, also an OMM protein, directly binds to DLP1 and is necessary and sufficient for mitochondrial recruitment of DLP1 during mitochondrial fission [49].”