Mechanics of membrane fusion
By L. Chernomordik, Michael M. Kozlov. Nature Structural &Molecular Biology, 2008
1,018 citations recorded by the source corpus.
Diverse membrane fusion reactions in biology involve close contact between two lipid bilayers, followed by the local distortion of the individual bilayers and reformation into a single, merged membrane. We consider the structures and energies of the fusion intermediates identified in experimental and theoretical work on protein-free lipid bilayers. On the basis of this analysis, we then discuss the conserved fusion-through-hemifusion pathway of merger between biological membranes and propose that the entire progression, from the close juxtaposition of membrane bilayers to the expansion of a fusion pore, is controlled by protein-generated membrane stresses.
Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/f596e1e29b74840a8db8a3a5ca14b4b57cc35fbf
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In Cell Biology
In Molecular Biology
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- J. Martinou
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- Douglas R. Green
- Jerry M. Adams
Citations in the corpus
- Mitochondria in Apoptosis: Bcl-2 family Members and Mitochondrial Dynamics (2011, background): “The stalk then expands to form a metastable nonbilayer membrane intermediate also called hemifission or hemifusion intermediate for membrane fission and fusion respectively (Chernomordik and Kozlov, 2008; Kozlovsky and Kozlov, 2003).”
- Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, background): “In contrast to hemifusion, fusion pores represent a connection betweenmergingmembranes involving both the outer and the inner leaflets (Chernomordik and Kozlov, 2008).”