Mitochondrial dynamics and apoptosis.

By D. Suen, Kristi L. Norris, R. Youle. Genes & Development, 2008

1,288 citations recorded by the source corpus.

In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting network. The molecular machinery that mediates this organelle fission and fusion is necessary to maintain mitochondrial integrity, perhaps by facilitating DNA or protein quality control. This network disintegrates during apoptosis at the time of cytochrome c release and prior to caspase activation, yielding more numerous and smaller mitochondria. Recent work shows that proteins involved in mitochondrial fission and fusion also actively participate in apoptosis induction. This review will cover the recent advances and presents competing models on how the mitochondrial fission and fusion machinery may intersect apoptosis pathways.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/91ce50a20968b7e89e7cc4cd7cab7128e6c05d0e

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Citations in the corpus

Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex (2010, background): “Perhaps it should not be a surprise then that mitofusins have been reported to perform numerous functions, including the regulation of mitochondrial fusion (Chan, 2006), endoplasmic reticulum (ER)–mitochondrial tethering (de Brito and Scorrano, 2008), apoptotic cell death and outer membrane permeabi”
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice (2009, background): “In contrast, the physiological significance of mitochondrial fission is less clearly defined; it is thought to be involved in apoptosi”
SLP‐2 is required for stress‐induced mitochondrial hyperfusion (2009, neutral): “Fission of mitochondria is required for the selective elimination of depolarized mitochondria (Twig et al , 2008), and it occurs during apoptosis (Suen et al , 2008).”
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations (2010, neutral): “Most studies on mammalian mitochondrial dynamics have been limited to cultured cells and neurons (Detmer and Chan, 2007a; Suen et al., 2008).”
miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1 (2011, background): “Mitochondria constantly undergo fusion and fission, which are necessary for the maintenance of organelle fidelit”
Mitochondrial fusion and fission in cell life and death (2010, background): “A key event in apoptosis is mitochondrial outer membrane permeabilization, which releases cytochrome c and other pro-apoptotic factors from the intermembrane space into the cytosol to trigger downstream cell death pathway”
Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle (2011, background): “The frequencies of fusion and fission events are balanced to maintain the overall morphology of the mitochondrial population (8, 41).”
Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases (2009, background): “When these protective mechanisms fail, mitochondrial fission can also promote apoptosis, an important topic that has been extensively reviewed (28).”
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice (2009, background): “Samples were postfixed, dehydrated, and embedded as described in the previous paragraph. on A ugust 21, 2017 jcb.rupress.org D ow nloaded from 815PHYSIOLOGICAL FUNCTION OF DRP1 • Wakabayashi et al. James, D.I., and J.C. Martinou.”
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells (2010, methodology): “Cells were then serial diluted Lee et al., 2004; Suen et al., 2008; Benard and Karbowski, 2009).”
Mitochondrial dynamics regulates migration and invasion of breast cancer cells (2012, background): “Altered mitochondrial dynamics has been linked to altered mitochondrial physiology and abnormal cell functions (15, 16), which has been implicated in many human diseases (17).”